Deletion of


Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
11 01 2023
Historique:
received: 03 06 2022
revised: 14 09 2022
accepted: 08 11 2022
pubmed: 24 11 2022
medline: 19 1 2023
entrez: 23 11 2022
Statut: ppublish

Résumé

The sensory region of the mammalian hearing organ contains two main cell types-hair cells and supporting cells. During development, Notch signaling plays an important role in whether a cell becomes either a hair cell or supporting cell by mediating lateral inhibition. However, once the cell fate decisions have been determined, little is understood about the role Notch plays in cochlear maturation. Here, we report that deletion of

Identifiants

pubmed: 36418183
pii: JNEUROSCI.1090-22.2022
doi: 10.1523/JNEUROSCI.1090-22.2022
pmc: PMC9838715
doi:

Substances chimiques

Notch1 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

199-210

Subventions

Organisme : NIDCD NIH HHS
ID : F31 DC018198
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC009250
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017767
Pays : United States

Informations de copyright

Copyright © 2023 the authors.

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Auteurs

Alison Heffer (A)

Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642.

Felicia A Gilels (FA)

Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642.
Departments of Pathology and Laboratory Medicine.

Amy E Kiernan (AE)

Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York 14642 amy_kiernan@urmc.rochester.edu.
Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642.

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Classifications MeSH