Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models.

Animals Mice Carbazoles / chemistry Cell Line Optical Imaging Prion Diseases / diagnosis PrPC Proteins / antagonists & inhibitors Protein Aggregates / drug effects
Carbazoles GN8 Prion protein Prions Theranostics

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Jan 2023
Historique:
received: 03 11 2021
revised: 20 05 2022
accepted: 08 11 2022
pubmed: 25 11 2022
medline: 6 12 2022
entrez: 24 11 2022
Statut: ppublish

Résumé

Prion diseases are characterized by the self-assembly of pathogenic misfolded scrapie isoforms (PrP

Identifiants

DOI: 10.1016/j.ejmech.2022.114923 PMID: 36423450
pubmed: 36423450
pii: S0223-5234(22)00825-X
doi: 10.1016/j.ejmech.2022.114923
pii:
doi:

Substances chimiques

Carbazoles 0
PrPC Proteins 0
Protein Aggregates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114923

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Matteo Staderini (M)

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.

Silvia Vanni (S)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy.

Arianna Colini Baldeschi (AC)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy.

Gabriele Giachin (G)

Department of Chemical Sciences (DiSC), University of Padua, Via F. Marzolo 1, 35131, Padova, Italy.

Marco Zattoni (M)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy.

Luigi Celauro (L)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy.

Chiara Ferracin (C)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy.

Edoardo Bistaffa (E)

Unit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milano, Italy.

Fabio Moda (F)

Unit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milano, Italy.

Daniel I Pérez (DI)

Centro de Investigaciones Biológicas Margarita Salas, CSIC, C. Ramiro de Maeztu, 9, 28040, Madrid, Spain.

Ana Martínez (A)

Centro de Investigaciones Biológicas Margarita Salas, CSIC, C. Ramiro de Maeztu, 9, 28040, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, C. de Melchor Fernández Almagro, 3, 28029, Madrid, Spain.

M Antonia Martín (MA)

Unidad de Química Analítica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.

Olmo Martín-Cámara (O)

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.

Ángel Cores (Á)

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.

Giulia Bianchini (G)

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain.

Robert Kammerer (R)

Friedrich-Loeffler-Institut Bundesforschungsinstitut für Tiergesundheit, Federal Research Institute for Animal Health, Südufer 10, 17493, Greifswald, Insel Riems, Germany.

J Carlos Menéndez (JC)

Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain. Electronic address: josecm@ucm.es.

Giuseppe Legname (G)

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), via Bonomea, 265, 34136, Trieste, Italy. Electronic address: legname@sissa.it.

Maria Laura Bolognesi (ML)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy. Electronic address: marialaura.bolognesi@unibo.it.

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Classifications MeSH

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questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Carbazoles › Bifunctional carbazole derivatives for...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Bifunctional carbazole derivatives for...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Bifunctional carbazole derivatives for...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladies à prions › Bifunctional carbazole derivatives for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Protéines PrPC › Bifunctional carbazole derivatives for...
questionsmedicales.fr › Structures macromoléculaires › Agrégats de protéines › Bifunctional carbazole derivatives for...