The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula.

Animals Mice Habenula / metabolism Naloxone / metabolism Neurons / metabolism Receptors, Opioid, mu / metabolism Reward Receptors, G-Protein-Coupled / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
24 11 2022
Historique:
received: 19 07 2022
accepted: 15 11 2022
entrez: 24 11 2022
pubmed: 25 11 2022
medline: 29 11 2022
Statut: epublish

Résumé

The mu opioid receptor (MOR) and the orphan GPR151 receptor are inhibitory G protein coupled receptors that are enriched in the habenula, a small brain region involved in aversion processing, addiction and mood disorders. While MOR expression in the brain is widespread, GPR151 expression is restricted to the habenula. In a previous report, we created conditional ChrnB4-Cre × Oprm1

Identifiants

DOI: 10.1038/s41598-022-24395-z PMID: 36424418 PMC: PMC9691715
pubmed: 36424418
doi: 10.1038/s41598-022-24395-z
pii: 10.1038/s41598-022-24395-z
pmc: PMC9691715
doi:

Substances chimiques

Naloxone 36B82AMQ7N
Receptors, Opioid, mu 0
Gpr151 protein, mouse 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

20234

Subventions

Organisme : NIDA NIH HHS
ID : P50 DA005010
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048796
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Florence Allain (F)

Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Canada.
INSERM U1114, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, CS60026, 67084, Strasbourg Cedex, France.

Michelle Carter (M)

Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Canada.

Sylvie Dumas (S)

Oramacell, 75006, Paris, France.

Emmanuel Darcq (E)

Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Canada.
INSERM U1114, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, CS60026, 67084, Strasbourg Cedex, France.

Brigitte L Kieffer (BL)

Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Canada. brigitte.kieffer@unistra.fr.
INSERM U1114, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, CS60026, 67084, Strasbourg Cedex, France. brigitte.kieffer@unistra.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Épithalamus › Habénula › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Naloxone › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Cellules › Neurones › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › The mu opioid receptor and the orphan receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › The mu opioid receptor and the orphan receptor...