Ketamine triggers a switch in excitatory neuronal activity across neocortex.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
08
11
2021
accepted:
13
10
2022
pubmed:
25
11
2022
medline:
12
1
2023
entrez:
24
11
2022
Statut:
ppublish
Résumé
The brain can become transiently disconnected from the environment while maintaining vivid, internally generated experiences. This so-called 'dissociated state' can occur in pathological conditions and under the influence of psychedelics or the anesthetic ketamine (KET). The cellular and circuit mechanisms producing the dissociative state remain poorly understood. We show in mice that KET causes spontaneously active neurons to become suppressed while previously silent neurons become spontaneously activated. This switch occurs in all cortical layers and different cortical regions, is induced by both systemic and cortical application of KET and is mediated by suppression of parvalbumin and somatostatin interneuron activity and inhibition of NMDA receptors and HCN channels. Combined, our results reveal two largely non-overlapping cortical neuronal populations-one engaged in wakefulness, the other contributing to the KET-induced brain state-and may lay the foundation for understanding how the brain might become disconnected from the surrounding environment while maintaining internal subjective experiences.
Identifiants
pubmed: 36424433
doi: 10.1038/s41593-022-01203-5
pii: 10.1038/s41593-022-01203-5
doi:
Substances chimiques
Ketamine
690G0D6V8H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-52Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : T32NS091006
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : NIH R01 EY020765
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : NIH R01GM088156-08
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM124023-01A1
Organisme : NIGMS NIH HHS
ID : R01 GM088156
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS113366
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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