In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario.
2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB)
3-dichloro-2-propyl)phosphate (TDCPP)
Bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP)
Flame retardant (FR)
In vitro neurotoxicity
Triphenyl phosphate (TPhP)
Tris(1
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
17
08
2022
revised:
19
10
2022
accepted:
19
11
2022
pubmed:
26
11
2022
medline:
3
1
2023
entrez:
25
11
2022
Statut:
ppublish
Résumé
Since 2004, some legacy flame retardants (FRs) were restricted or removed from the European markets due to their concern on human health. Both organophosphorus FRs (OPFRs) and novel brominated FRs (NBFRs) have replaced them because they are presumably safer and less persistent emerging FRs (EFRs) and their exposure is currently occurring in indoor environments at high levels. Little is known about the neurotoxic potential risk of these EFRs in humans. The present study was aimed at assessing the acute neurotoxicity potential of Tris(1, 3-dichloro-2-propyl)phosphate (TDCPP), triphenyl phosphate (TPhP), Bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) on human neuroblastoma cells (SH-SY5Y). SH-SY5Y were exposed to these EFRs at low concentrations -ranging 2.5-20 μM. during 2-24 h. We investigated viability, mitochondrial function, oxidative stress, inflammatory response, as well as neural plasticity and development. The results have demonstrated that selected EFRs (TDCPP, TPhP, EH-TBB and BEH-TBP) did not impair neural function on SH-SY5Y as acute response. To the best of our knowledge, this has been the first study focused on evaluating the neural affection of TPhP on SH-SY5Y cells and of EH-TBB and BEH-TBP on neural cells. We also assessed for the first time almost all endpoints after FR exposure on neural cell lines.
Identifiants
pubmed: 36427757
pii: S0887-2333(22)00221-1
doi: 10.1016/j.tiv.2022.105523
pii:
doi:
Substances chimiques
Flame Retardants
0
Dust
0
triphenyl phosphate
YZE19Z66EA
Organophosphates
0
Organophosphorus Compounds
0
Halogenated Diphenyl Ethers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105523Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The author declare that they have no known competing financial interest or personal relationship that could have appeared to influence the work reported in this paper.