Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule.
behavioural phenotypes
bioenergetics
glyoxalase
homeostasis
methylglyoxal
neurodegenerative
side-product
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Nov 2022
15 Nov 2022
Historique:
received:
19
10
2022
revised:
09
11
2022
accepted:
11
11
2022
entrez:
26
11
2022
pubmed:
27
11
2022
medline:
30
11
2022
Statut:
epublish
Résumé
Advances in molecular biology technology have piqued tremendous interest in glycometabolism and bioenergetics in homeostasis and neural development linked to ageing and age-related diseases. Methylglyoxal (MGO) is a by-product of glycolysis, and it can covalently modify proteins, nucleic acids, and lipids, leading to cell growth inhibition and, eventually, cell death. MGO can alter intracellular calcium homeostasis, which is a major cell-permeant precursor to advanced glycation end-products (AGEs). As side-products or signalling molecules, MGO is involved in several pathologies, including neurodevelopmental disorders, ageing, and neurodegenerative diseases. In this review, we demonstrate that MGO (the metabolic side-product of glycolysis), the GLO system, and their analogous relationship with behavioural phenotypes, epigenetics, ageing, pain, and CNS degeneration. Furthermore, we summarise several therapeutic approaches that target MGO and the glyoxalase (GLO) system in neurodegenerative diseases.
Identifiants
pubmed: 36432007
pii: molecules27227905
doi: 10.3390/molecules27227905
pmc: PMC9696358
pii:
doi:
Substances chimiques
Pyruvaldehyde
722KLD7415
Lactoylglutathione Lyase
EC 4.4.1.5
Magnesium Oxide
3A3U0GI71G
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Genes Chromosomes Cancer. 2010 Aug;49(8):711-25
pubmed: 20544845
Antioxid Redox Signal. 2013 Sep 10;19(8):813-22
pubmed: 23249101
Redox Biol. 2018 Apr;14:218-228
pubmed: 28961512
J Biol Chem. 2006 Sep 8;281(36):26702-13
pubmed: 16831876
Diabetes. 2009 Dec;58(12):2893-903
pubmed: 19720799
Front Genet. 2012 Nov 19;3:250
pubmed: 23181072
Neurobiol Aging. 2014 Jun;35(6):1469-72
pubmed: 24388766
Nat Protoc. 2014 Aug;9(8):1969-79
pubmed: 25058644
Ann Neurol. 2009 Jun;65(6):650-7
pubmed: 19557866
Br J Psychiatry. 2011 Sep;199(3):245-6
pubmed: 21881099
Eur J Endocrinol. 2011 Mar;164(3):371-9
pubmed: 21205874
Neurotox Res. 2018 Feb;33(2):412-421
pubmed: 28900826
Exp Clin Endocrinol Diabetes. 2011 Jun;119(6):362-5
pubmed: 21472665
J Biol Chem. 2017 Sep 22;292(38):15758-15776
pubmed: 28611063
Nat Rev Neurosci. 2010 Jul;11(7):490-502
pubmed: 20559336
Behav Pharmacol. 2006 Jun;17(4):349-56
pubmed: 16914953
Diabetes Metab. 2001 Nov;27(5 Pt 1):535-42
pubmed: 11694852
Cereb Cortex. 2005 Feb;15(2):211-20
pubmed: 15238435
J Clin Invest. 2012 Jun;122(6):2306-15
pubmed: 22585572
J Neurochem. 2010 Jun;113(5):1240-51
pubmed: 20345757
Amino Acids. 2008 Jun;35(1):29-36
pubmed: 18008028
Nat Rev Neurosci. 2012 Mar 20;13(4):251-66
pubmed: 22430017
Cell Metab. 2015 Sep 1;22(3):437-47
pubmed: 26235423
Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):124-7
pubmed: 17722011
Neurobiol Aging. 2006 Jun;27(6):815-22
pubmed: 15950319
Amino Acids. 2012 Apr;42(4):1221-36
pubmed: 20949363
Semin Cell Dev Biol. 2011 May;22(3):293-301
pubmed: 21320620
Aging Cell. 2008 Mar;7(2):260-9
pubmed: 18221415
J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66
pubmed: 22027938
Chem Biol Interact. 2008 Feb 15;171(3):251-71
pubmed: 18164697
Transl Res. 2012 May;159(5):355-65
pubmed: 22500508
Aging Cell. 2014 Jun;13(3):519-28
pubmed: 24612481
Free Radic Biol Med. 2000 Jun 15;28(12):1708-16
pubmed: 10946212
Cell Metab. 2018 Sep 4;28(3):337-352
pubmed: 30184484
Biochem J. 2012 Apr 1;443(1):213-22
pubmed: 22188542
Biochem Pharmacol. 2010 May 15;79(10):1379-86
pubmed: 20096667
Mech Ageing Dev. 2011 Nov-Dec;132(11-12):583-7
pubmed: 22079406
Free Radic Biol Med. 2014 Feb;67:195-210
pubmed: 24252591
Neurobiol Aging. 2011 May;32(5):778-90
pubmed: 19482376
Gen Pharmacol. 1996 Jun;27(4):565-73
pubmed: 8853285
Exp Biol Med (Maywood). 2017 May;242(10):1095-1103
pubmed: 28361585
J Neurosci. 2015 Mar 11;35(10):4168-78
pubmed: 25762664
Biol Trace Elem Res. 2012 Nov;149(2):248-61
pubmed: 22535598
Invest Ophthalmol Vis Sci. 2003 Feb;44(2):521-8
pubmed: 12556378
Free Radic Biol Med. 2018 Feb 1;115:202-218
pubmed: 29170092
Eur J Pharmacol. 2008 Sep 28;593(1-3):30-5
pubmed: 18692042
Nat Rev Neurosci. 2009 May;10(5):333-44
pubmed: 19339974
Nat Med. 2017 Jun;23(6):753-762
pubmed: 28436957
J Physiol. 2010 Jun 1;588(Pt 11):1861-9
pubmed: 20308251
Brain. 2017 May 1;140(5):1399-1419
pubmed: 28398476
Front Mol Neurosci. 2018 Mar 05;11:70
pubmed: 29556176
Alcohol Clin Exp Res. 2018 May;42(5):869-878
pubmed: 29532486
J Neurosci. 2016 Sep 7;36(36):9313-25
pubmed: 27605608
Free Radic Res. 2010 Jan;44(1):101-7
pubmed: 19886746
Neurobiol Aging. 2007 Jan;28(1):29-41
pubmed: 16427160
Biochem Soc Trans. 2003 Dec;31(Pt 6):1343-8
pubmed: 14641060
J Biol Chem. 2012 Aug 17;287(34):28291-306
pubmed: 22740698
N Engl J Med. 1995 Nov 9;333(19):1242-7
pubmed: 7566000
Semin Cell Dev Biol. 2011 May;22(3):318-25
pubmed: 21315826
Gerontology. 2013;59(5):427-37
pubmed: 23797271
Biochem J. 2013 Jul 1;453(1):1-15
pubmed: 23763312
Nature. 2005 Dec 1;438(7068):662-6
pubmed: 16244648
Mol Cell Biochem. 2010 Feb;335(1-2):137-46
pubmed: 19756958
Nature. 2006 Oct 19;443(7113):787-95
pubmed: 17051205
Trends Pharmacol Sci. 2008 Dec;29(12):609-15
pubmed: 18838179
Nature. 2018 Oct;562(7728):600-604
pubmed: 30323285
Trends Neurosci. 2013 Jul;36(7):396-404
pubmed: 23639382
Eur J Pharmacol. 2014 Oct 15;741:186-94
pubmed: 25160740
Free Radic Biol Med. 2018 May 20;120:228-238
pubmed: 29559323
Science. 2017 Jul 14;357(6347):208-211
pubmed: 28596309
Mol Cell Biochem. 2007 Aug;302(1-2):35-42
pubmed: 17318407
Epilepsia. 2013 Apr;54(4):649-57
pubmed: 23409935
Genes Brain Behav. 2009 Nov;8(8):817-28
pubmed: 19751396
Science. 2015 Mar 20;347(6228):1362-7
pubmed: 25792327
Arch Gen Psychiatry. 2010 Jun;67(6):589-97
pubmed: 20530008
J Clin Invest. 1998 Mar 1;101(5):1142-7
pubmed: 9486985
G3 (Bethesda). 2013 Aug 07;3(8):1311-3
pubmed: 23733890
Hum Mol Genet. 2012 Jul 15;21(14):3215-25
pubmed: 22523093
Behav Neurosci. 2004 Dec;118(6):1450-4
pubmed: 15598155
Neurosci Lett. 2014 May 21;569:99-103
pubmed: 24631568
Redox Biol. 2017 Apr;11:577-585
pubmed: 28110213
Free Radic Biol Med. 2013 Jan;54:51-61
pubmed: 23108103
Nature. 2015 Jan 15;517(7534):284-92
pubmed: 25592533
Nat Med. 2012 Jun;18(6):926-33
pubmed: 22581285
Mol Neurobiol. 2018 Nov;55(11):8754-8763
pubmed: 29594935
Mol Cell Proteomics. 2011 Dec;10(12):M111.008110
pubmed: 21862759
Diabetes. 2010 Jan;59(1):249-55
pubmed: 19833897
Diabetologia. 2011 Aug;54(8):2174-82
pubmed: 21633909
Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233
pubmed: 30150385
Amino Acids. 2012 Apr;42(4):1133-42
pubmed: 20963454
J Neurochem. 2006 Dec;99(5):1413-24
pubmed: 17074066
Am J Nephrol. 2007;27(6):605-14
pubmed: 17823506
Free Radic Res. 2016;50(11):1173-1187
pubmed: 27596733
Bioinformatics. 2007 Sep 1;23(17):2239-46
pubmed: 17827208
Am J Pathol. 2011 Dec;179(6):2810-21
pubmed: 22001178
FEBS J. 2005 Sep;272(17):4521-31
pubmed: 16128820
Cell Rep. 2016 Oct 18;17(4):1022-1036
pubmed: 27760310
Recent Pat Cardiovasc Drug Discov. 2007 Jun;2(2):89-99
pubmed: 18221107
Diabetes Care. 2017 Apr;40(4):591-598
pubmed: 28148544