Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice.
diastolic dysfunction
endothelium
mineralocorticoid receptor
mitochondria
oxidative stress
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
pmc-release:
01
01
2024
pubmed:
29
11
2022
medline:
31
12
2022
entrez:
28
11
2022
Statut:
ppublish
Résumé
Widespread consumption of diets high in fat and fructose (Western diet, WD) has led to increased prevalence of obesity and diastolic dysfunction (DD). DD is a prominent feature of heart failure with preserved ejection fraction (HFpEF). However, the underlying mechanisms of DD are poorly understood, and treatment options are still limited. We have previously shown that deletion of the cell-specific mineralocorticoid receptor in endothelial cells (ECMR) abrogates DD induced by WD feeding in female mice. However, the specific role of ECMR activation in the pathogenesis of DD in male mice has not been clarified. Therefore, we fed 4-wk-old ECMR knockout (ECMRKO) male mice and littermates (LM) with either a WD or chow diet (CD) for 16 wk. WD feeding resulted in DD characterized by increased left ventricle (LV) filling pressure (
Identifiants
pubmed: 36440901
doi: 10.1152/ajpregu.00274.2021
pmc: PMC9799154
doi:
Substances chimiques
Receptors, Mineralocorticoid
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Banques de données
figshare
['10.6084/m9.figshare.21561684']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
R90-R101Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL132012
Pays : United States
Organisme : BLRD VA
ID : I01 BX003391
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142770
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124329
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124155
Pays : United States
Organisme : BLRD VA
ID : I01 BX001981
Pays : United States
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