Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla.
Cetartiodactyla
RNase9
gene duplication
gene loss
Journal
Science China. Life sciences
ISSN: 1869-1889
Titre abrégé: Sci China Life Sci
Pays: China
ID NLM: 101529880
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
29
07
2022
accepted:
30
08
2022
medline:
10
5
2023
pubmed:
29
11
2022
entrez:
28
11
2022
Statut:
ppublish
Résumé
RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease (RNase) A superfamily, a gene family that is widely used as a model for molecular evolutionary studies. Here, we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this clade. Unexpectedly, RNase9 experienced an evolutionary scenario of "birth and death" in Ruminantia, and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues (epididymis, vas deferens or prostate). This expression pattern combined with the estimate that these genes duplicated during the middle Eocene, a time when Ruminantia become a successful lineage, suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this period. In contrast, all RNase9 genes were lost in the Cetacean lineage, which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean resources. This study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla, providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment.
Identifiants
pubmed: 36443512
doi: 10.1007/s11427-022-2195-x
pii: 10.1007/s11427-022-2195-x
doi:
Substances chimiques
Ribonucleases
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1170-1182Informations de copyright
© 2022. Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.
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