A shift towards succinate-producing Prevotella in the ruminal microbiome challenged with monensin.
Prevotellaceae
metabolome
metaproteome
monensin
rumen
Journal
Proteomics
ISSN: 1615-9861
Titre abrégé: Proteomics
Pays: Germany
ID NLM: 101092707
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
21
11
2022
received:
03
06
2022
accepted:
23
11
2022
medline:
22
11
2023
pubmed:
30
11
2022
entrez:
29
11
2022
Statut:
ppublish
Résumé
The time-resolved impact of monensin on the active rumen microbiome was studied in a rumen-simulating technique (Rusitec) with metaproteomic and metabolomic approaches. Monensin treatment caused a decreased fibre degradation potential that was observed by the reduced abundance of proteins assigned to fibrolytic bacteria and glycoside hydrolases, sugar transporters and carbohydrate metabolism. Decreased proteolytic activities resulted in reduced amounts of ammonium as well as branched-chain fatty acids. The family Prevotellaceae exhibited increased resilience in the presence of monensin, with a switch of the metabolism from acetate to succinate production. Prevotella species harbour a membrane-bound electron transfer complex, which drives the reduction of fumarate to succinate, which is the substrate for propionate production in the rumen habitat. Besides the increased succinate production, a concomitant depletion of methane concentration was observed upon monensin exposure. Our study demonstrates that Prevotella sp. shifts its metabolism successfully in response to monensin exposure and Prevotellaceae represents the key bacterial family stabilizing the rumen microbiota during exposure to monensin.
Identifiants
pubmed: 36444514
doi: 10.1002/pmic.202200121
doi:
Substances chimiques
Monensin
906O0YJ6ZP
Succinic Acid
AB6MNQ6J6L
Succinates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200121Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 327953272
Informations de copyright
© 2022 The Authors. Proteomics published by Wiley-VCH GmbH.
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