Comparison of serum and whole blood concentrations in quetiapine overdose cases.
Acute quetiapine poisoning
Diagnosis
Therapeutic drug concentrations
Whole blood/serum concentration ratios
Journal
Forensic toxicology
ISSN: 1860-8965
Titre abrégé: Forensic Toxicol
Pays: Japan
ID NLM: 101315563
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
02
12
2021
accepted:
25
02
2022
entrez:
1
12
2022
pubmed:
2
12
2022
medline:
6
12
2022
Statut:
ppublish
Résumé
This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC-MS). Quetiapine concentrations in whole blood and serum samples ranged widely from 5.4 to 2780 ng/mL and 9.9 to 2500 ng/mL, respectively. The whole blood/serum concentration ratio was 0.5-1.1 and increased together with an increase in whole blood and serum quetiapine concentrations. The ratio was reversed at around 2500 ng/mL to > 1. Our findings suggest that whole blood concentrations are more useful than serum concentrations in diagnosing quetiapine poisonings.
Identifiants
pubmed: 36454407
doi: 10.1007/s11419-022-00618-w
pii: 10.1007/s11419-022-00618-w
doi:
Substances chimiques
Quetiapine Fumarate
2S3PL1B6UJ
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-406Informations de copyright
© 2022. The Author(s), under exclusive licence to Japanese Association of Forensic Toxicology.
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