The gut microbiome: a core regulator of metabolism.
diabetes
metabolism
obesity
Journal
The Journal of endocrinology
ISSN: 1479-6805
Titre abrégé: J Endocrinol
Pays: England
ID NLM: 0375363
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
received:
02
11
2022
accepted:
02
12
2022
pubmed:
3
12
2022
medline:
21
1
2023
entrez:
2
12
2022
Statut:
epublish
Résumé
The human body is inhabited by numerous bacteria, fungi, and viruses, and each part has a unique microbial community structure. The gastrointestinal tract harbors approximately 100 trillion strains comprising more than 1000 bacterial species that maintain symbiotic relationships with the host. The gut microbiota consists mainly of the phyla Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Of these, Firmicutes and Bacteroidetes constitute 70-90% of the total abundance. Gut microbiota utilize nutrients ingested by the host, interact with other bacterial species, and help maintain healthy homeostasis in the host. In recent years, it has become increasingly clear that a breakdown of the microbial structure and its functions, known as dysbiosis, is associated with the development of allergies, autoimmune diseases, cancers, and arteriosclerosis, among others. Metabolic diseases, such as obesity and diabetes, also have a causal relationship with dysbiosis. The present review provides a brief overview of the general roles of the gut microbiota and their relationship with metabolic disorders.
Identifiants
pubmed: 36458804
doi: 10.1530/JOE-22-0111
pii: e220111
pmc: PMC9874984
doi:
pii:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
Cell Metab. 2009 Apr;9(4):311-26
pubmed: 19356713
Cell Metab. 2017 May 2;25(5):1054-1062.e5
pubmed: 28467925
NPJ Biofilms Microbiomes. 2019 Oct 4;5(1):28
pubmed: 31602309
Science. 2013 Sep 6;341(6150):1241214
pubmed: 24009397
Science. 2004 Oct 15;306(5695):457-61
pubmed: 15486293
Nat Med. 2017 Jan;23(1):107-113
pubmed: 27892954
Diabetes. 2015 Sep;64(9):3203-17
pubmed: 26023106
Gut Microbes. 2021 Jan-Dec;13(1):1987783
pubmed: 34693878
Science. 2018 May 25;360(6391):
pubmed: 29798856
Science. 2010 Apr 9;328(5975):228-31
pubmed: 20203013
Gut Pathog. 2011 May 23;3(1):8
pubmed: 21605455
J Bacteriol. 2004 Apr;186(7):2099-106
pubmed: 15028695
Lobund reports. 1946 Nov;(1):1-84
pubmed: 20247584
Cell. 2015 Oct 8;163(2):367-80
pubmed: 26411289
Front Microbiol. 2017 Nov 07;8:2171
pubmed: 29163449
J Biol Chem. 2003 Mar 14;278(11):9435-40
pubmed: 12524422
Mol Cell Endocrinol. 2013 Apr 10;368(1-2):17-29
pubmed: 22609541
Gut Microbes. 2022 Jan-Dec;14(1):2031696
pubmed: 35130127
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Nutr J. 2009 Oct 21;8:49
pubmed: 19845958
Front Genet. 2015 Apr 20;6:148
pubmed: 25941533
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Cell Metab. 2013 Feb 5;17(2):225-35
pubmed: 23395169
Nat Commun. 2013;4:1829
pubmed: 23652017
Sci Rep. 2022 Feb 10;12(1):2265
pubmed: 35145140
Diabetes. 2010 Dec;59(12):3049-57
pubmed: 20876719
Diabetes Care. 2017 Jan;40(1):54-62
pubmed: 27999002
Surg Endosc. 2022 Oct;36(10):7312-7324
pubmed: 35182212
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84
pubmed: 17210919
Mol Metab. 2016 Nov 04;6(1):48-60
pubmed: 28123937
Nat Commun. 2020 Nov 18;11(1):5881
pubmed: 33208748
Nature. 2020 Feb;578(7794):284-289
pubmed: 32025031
PLoS One. 2016 Sep 06;11(9):e0162192
pubmed: 27598004
Nutrients. 2020 Jul 21;12(7):
pubmed: 32708278
Gut Microbes. 2020 Sep 2;11(5):1231-1245
pubmed: 32167023
Science. 2017 Apr 21;356(6335):315-319
pubmed: 28428425
Nat Med. 2016 Apr;22(4):421-6
pubmed: 26950361
iScience. 2021 Apr 16;24(5):102445
pubmed: 33997711
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9178-83
pubmed: 16740661
Diabetes. 2012 Feb;61(2):364-71
pubmed: 22190648
J Endocrinol. 2021 Feb;248(2):R67-R82
pubmed: 33295880
Diabetes Care. 2022 Mar 1;45(3):555-563
pubmed: 35045174
Pharmacol Res. 2017 Sep;123:103-113
pubmed: 28668709
Nature. 2006 Jan 26;439(7075):484-9
pubmed: 16400329
J Clin Invest. 2016 Dec 1;126(12):4430-4443
pubmed: 27775551
Am J Clin Nutr. 2008 Mar;87(3):534-8
pubmed: 18326589
Appl Environ Microbiol. 2020 Mar 18;86(7):
pubmed: 31953338
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23
pubmed: 15505215
Nutrients. 2020 Jan 21;12(2):
pubmed: 31973130
Science. 2006 Aug 25;313(5790):1137-40
pubmed: 16931765
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1006-11
pubmed: 16410358
Clin Drug Investig. 2018 Jun;38(6):545-552
pubmed: 29508311
Sci Rep. 2018 Jun 27;8(1):9749
pubmed: 29950689
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
Front Microbiol. 2018 Feb 14;9:213
pubmed: 29491857
Nat Commun. 2020 Apr 22;11(1):1922
pubmed: 32321922
Metabolism. 2013 Jul;62(7):961-9
pubmed: 23375209
Cell Host Microbe. 2019 May 8;25(5):668-680.e7
pubmed: 31071294
Nutr Diabetes. 2011 Jul 18;1:e12
pubmed: 23154580
BMC Microbiol. 2020 Oct 31;20(1):330
pubmed: 33129264
Nat Genet. 2016 Nov;48(11):1396-1406
pubmed: 27723756
EMBO Mol Med. 2011 Sep;3(9):559-72
pubmed: 21735552
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6458-6463
pubmed: 29866843
Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G341-9
pubmed: 26159695
ISME J. 2013 Apr;7(4):707-17
pubmed: 23190729
Gut. 2014 May;63(5):727-35
pubmed: 23804561
Int J Obes (Lond). 2016 Apr;40(4):615-21
pubmed: 26486756
Nature. 2006 Dec 21;444(7122):1022-3
pubmed: 17183309
Cell Metab. 2020 Oct 6;32(4):643-653.e4
pubmed: 32783890
J Microbiol. 2022 Jan;60(1):118-127
pubmed: 34964947
Metabolites. 2021 Dec 27;12(1):
pubmed: 35050143
Immunol Rev. 2013 Mar;252(1):164-82
pubmed: 23405904
Am J Physiol Cell Physiol. 2014 Dec 1;307(11):C979-85
pubmed: 25273884
Nature. 2008 Oct 23;455(7216):1109-13
pubmed: 18806780
Nat Commun. 2019 Sep 5;10(1):4007
pubmed: 31488836
Cell. 2015 Dec 17;163(7):1585-95
pubmed: 26687352
Nat Med. 2017 Jul;23(7):859-868
pubmed: 28628112
Int J Mol Sci. 2019 Jan 21;20(2):
pubmed: 30669548
J Lipid Res. 2010 Apr;51(4):771-84
pubmed: 19783811
JAMA Surg. 2018 May 1;153(5):427-434
pubmed: 29214306
Obesity (Silver Spring). 2010 Jan;18(1):190-5
pubmed: 19498350
Clin Transl Immunology. 2016 May 13;5(5):e82
pubmed: 27350881
Am J Clin Nutr. 2013 Jul;98(1):16-24
pubmed: 23719559
Trends Mol Med. 2020 Feb;26(2):137-140
pubmed: 31862244
Genome Biol. 2019 Nov 1;20(1):219
pubmed: 31672155
Cell. 2018 Nov 1;175(4):947-961.e17
pubmed: 30401435
Science. 2017 Oct 20;358(6361):359-365
pubmed: 29051379
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
Int J Obes (Lond). 2015 Mar;39(3):424-9
pubmed: 25109781
Cell. 2014 Nov 6;159(4):789-99
pubmed: 25417156
Cell. 2014 Jan 16;156(1-2):123-33
pubmed: 24439373
Cell. 2000 Sep 15;102(6):731-44
pubmed: 11030617
J Clin Invest. 2022 Apr 1;132(7):
pubmed: 35362479
Gut. 2015 Jun;64(6):872-83
pubmed: 25080446
OMICS. 2019 Oct;23(10):477-485
pubmed: 31589561
Science. 2011 Oct 7;334(6052):105-8
pubmed: 21885731
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
J Physiol. 2017 Jan 15;595(2):541-555
pubmed: 27510655
Gut. 2019 Jan;68(1):70-82
pubmed: 29899081
Br J Nutr. 2010 Feb;103(3):335-8
pubmed: 19849869
Diabetes Obes Metab. 2022 Jul;24(7):1224-1234
pubmed: 35257467
J Nutr. 2019 Jun 1;149(6):1075-1088
pubmed: 31006815
Sci Rep. 2020 Mar 26;10(1):5544
pubmed: 32218475
World J Gastrointest Pathophysiol. 2017 Aug 15;8(3):117-126
pubmed: 28868181
Curr Obes Rep. 2019 Sep;8(3):229-242
pubmed: 31197613
Nutrients. 2021 Sep 26;13(10):
pubmed: 34684379
PLoS One. 2020 Apr 29;15(4):e0230895
pubmed: 32348307
Eur Heart J. 2017 Oct 14;38(39):2948-2956
pubmed: 29020409
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72
pubmed: 18931303
Nature. 2021 Nov;599(7885):458-464
pubmed: 34325466
Science. 2011 Jan 21;331(6015):337-41
pubmed: 21205640
Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G966-78
pubmed: 22241860
J Nutr. 2013 Apr;143(4):417-23
pubmed: 23343669
Nat Commun. 2015 Dec 15;6:10166
pubmed: 26670557
Nature. 2009 Oct 29;461(7268):1282-6
pubmed: 19865172
Int J Mol Sci. 2022 Feb 19;23(4):
pubmed: 35216439
Hepatology. 2011 Jan;53(1):96-105
pubmed: 21254165
Nature. 2014 May 8;509(7499):183-8
pubmed: 24670636
Nat Rev Endocrinol. 2016 Mar;12(3):154-67
pubmed: 26729037
Nature. 2019 Nov;575(7783):505-511
pubmed: 31723265
Dig Liver Dis. 2014 Apr;46(4):302-12
pubmed: 24411485
Cell Metab. 2020 Sep 1;32(3):379-390.e3
pubmed: 32652044
Nutr Res. 2021 Nov;95:35-53
pubmed: 34798467
Mol Metab. 2018 May;11:84-95
pubmed: 29656109
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Nat Med. 2011 Apr;17(4):448-53
pubmed: 21423183
Sci Rep. 2021 Dec 10;11(1):23813
pubmed: 34893681
iScience. 2019 Sep 27;19:676-690
pubmed: 31472342
Nat Commun. 2015 Jul 02;6:7629
pubmed: 26134028
Science. 2019 Jun 21;364(6446):1179-1184
pubmed: 31221858
Nat Rev Microbiol. 2014 Oct;12(10):661-72
pubmed: 25198138
Nature. 2022 Mar;603(7903):907-912
pubmed: 35296854
Gut. 1987 Oct;28(10):1221-7
pubmed: 3678950
Am J Transl Res. 2017 Mar 15;9(3):1243-1254
pubmed: 28386350
Cell Metab. 2016 Jul 12;24(1):41-50
pubmed: 27320064
Sci Rep. 2017 May 24;7(1):2360
pubmed: 28539646
PLoS One. 2009 Sep 23;4(9):e7125
pubmed: 19774074
J Autoimmun. 2018 Feb;87:38-49
pubmed: 29290521
Nature. 2011 Jan 27;469(7331):543-7
pubmed: 21270894
Cell Rep. 2018 Mar 13;22(11):3072-3086
pubmed: 29539432
Clin Nutr. 2017 Aug;36(4):1097-1104
pubmed: 27595636
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Surg Obes Relat Dis. 2019 Nov;15(11):1888-1895
pubmed: 31648978
Obesity (Silver Spring). 2011 Nov;19(11):2280-2
pubmed: 21852815
Nat Rev Endocrinol. 2015 Mar;11(3):182-90
pubmed: 25488483
Cell. 2014 Aug 14;158(4):705-721
pubmed: 25126780
BMC Gastroenterol. 2015 Aug 11;15:100
pubmed: 26261039
J Lipid Res. 2013 Sep;54(9):2325-40
pubmed: 23821742
Cell Host Microbe. 2019 Aug 14;26(2):252-264.e10
pubmed: 31399369
Nature. 2013 Aug 29;500(7464):541-6
pubmed: 23985870
Diabetologia. 2012 Sep;55(9):2343-7
pubmed: 22696033
J Gastroenterol Hepatol. 2016 Aug;31(8):1462-9
pubmed: 26699443
J Biosci. 2012 Sep;37(4):647-57
pubmed: 22922190
Obes Surg. 2020 Jun;30(6):2345-2361
pubmed: 32152837
World J Gastroenterol. 2011 Feb 28;17(8):1076-81
pubmed: 21448362
Trends Microbiol. 2016 Jul;24(7):523-524
pubmed: 26996766
Diabetes Care. 2011 Aug;34(8):1809-15
pubmed: 21636801
FEBS Lett. 2012 May 21;586(10):1547-54
pubmed: 22673524
Diabetes Care. 2018 Oct;41(10):2178-2186
pubmed: 30100563
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
J Infect Dis. 2007 Oct 1;196(7):978-85
pubmed: 17763317
Nat Med. 2015 Feb;21(2):159-65
pubmed: 25559344
Obes Surg. 2022 May;32(5):1439-1450
pubmed: 35188608
J Clin Biochem Nutr. 2016 Jul;59(1):65-70
pubmed: 27499582
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
Cell Host Microbe. 2015 Feb 11;17(2):260-73
pubmed: 25662751
Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17808-13
pubmed: 24127592
Gut Microbes. 2020;11(1):63-76
pubmed: 31138061
Clin Perinatol. 1996 Jun;23(2):211-28
pubmed: 8780902
Nature. 2013 Jul 4;499(7456):97-101
pubmed: 23803760
mSystems. 2021 Feb 16;6(1):
pubmed: 33594006
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476
pubmed: 15388697
Genome Biol. 2017 Apr 13;18(1):70
pubmed: 28407784
Am J Clin Nutr. 2011 Mar;93(3):578-85
pubmed: 21248183
Cell Host Microbe. 2016 Apr 13;19(4):443-54
pubmed: 27078066
Am J Clin Nutr. 2008 May;87(5):1219-23
pubmed: 18469242
Immunity. 2014 Jan 16;40(1):128-39
pubmed: 24412617
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
Obes Facts. 2016;9(1):1-11
pubmed: 26745497
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2120028119
pubmed: 35878027
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
Nat Commun. 2015 Jun 23;6:7320
pubmed: 26102221
Science. 2005 Jun 10;308(5728):1635-8
pubmed: 15831718
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2289-2299
pubmed: 32855266
Appl Environ Microbiol. 2000 Apr;66(4):1654-61
pubmed: 10742256
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
Surg Obes Relat Dis. 2020 Jul;16(7):852-862
pubmed: 32360114
Biology (Basel). 2022 Feb 16;11(2):
pubmed: 35205184
Science. 2017 Aug 11;357(6351):570-575
pubmed: 28798125
Diabetes. 2011 Jul;60(7):1861-71
pubmed: 21593203
Hepatology. 2016 Mar;63(3):764-75
pubmed: 26600078
N Engl J Med. 2013 Apr 25;368(17):1575-84
pubmed: 23614584
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8030-5
pubmed: 21518883