Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease.
Journal
The Cochrane database of systematic reviews
ISSN: 1469-493X
Titre abrégé: Cochrane Database Syst Rev
Pays: England
ID NLM: 100909747
Informations de publication
Date de publication:
02 12 2022
02 12 2022
Historique:
entrez:
2
12
2022
pubmed:
3
12
2022
medline:
6
12
2022
Statut:
epublish
Résumé
Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. Therefore, bronchodilators may be useful in the treatment of acute chest syndrome. This is an update of a previously published Cochrane Review. The aim of the review is to determine whether the use of inhaled, short-acting bronchodilators for acute chest syndrome reduces morbidity and mortality in people with sickle cell disease and to assess whether this treatment causes adverse effects. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. Additional searches were carried out on MEDLINE (1966 to 2004) and Embase (1981 to 2004) and ongoing trial registries (28 September 2022). Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 25 July 2022. Randomised or quasi-randomised controlled trials. Trials using quasi-randomisation methods will be included in future updates of this review if there is sufficient evidence that the treatment and control groups are similar at baseline. We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease. We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease. If bronchial hyper-responsiveness is an important component of some episodes of acute chest syndrome in people with sickle cell disease, the use of inhaled bronchodilators may be indicated. There is need for a well-designed, adequately-powered randomised controlled trial to assess the benefits and risks of the addition of inhaled bronchodilators to established therapies for acute chest syndrome in people with sickle cell disease.
Sections du résumé
BACKGROUND
Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. Therefore, bronchodilators may be useful in the treatment of acute chest syndrome. This is an update of a previously published Cochrane Review.
OBJECTIVES
The aim of the review is to determine whether the use of inhaled, short-acting bronchodilators for acute chest syndrome reduces morbidity and mortality in people with sickle cell disease and to assess whether this treatment causes adverse effects.
SEARCH METHODS
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. Additional searches were carried out on MEDLINE (1966 to 2004) and Embase (1981 to 2004) and ongoing trial registries (28 September 2022). Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 25 July 2022.
SELECTION CRITERIA
Randomised or quasi-randomised controlled trials. Trials using quasi-randomisation methods will be included in future updates of this review if there is sufficient evidence that the treatment and control groups are similar at baseline.
DATA COLLECTION AND ANALYSIS
We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease.
MAIN RESULTS
We found no trials investigating the use of bronchodilators for acute chest syndrome in people with sickle cell disease.
AUTHORS' CONCLUSIONS
If bronchial hyper-responsiveness is an important component of some episodes of acute chest syndrome in people with sickle cell disease, the use of inhaled bronchodilators may be indicated. There is need for a well-designed, adequately-powered randomised controlled trial to assess the benefits and risks of the addition of inhaled bronchodilators to established therapies for acute chest syndrome in people with sickle cell disease.
Identifiants
pubmed: 36458811
doi: 10.1002/14651858.CD003733.pub5
pmc: PMC9717338
doi:
Substances chimiques
Bronchodilator Agents
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
CD003733Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Références
N Engl J Med. 2000 Jun 22;342(25):1855-65
pubmed: 10861320
Bull World Health Organ. 2001;79(8):704-12
pubmed: 11545326
Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006957
pubmed: 18254121
Am J Dis Child. 1991 Jun;145(6):603-4
pubmed: 2035485
Blood. 1994 Jul 15;84(2):643-9
pubmed: 7517723
Int J Epidemiol. 2002 Feb;31(1):140-9
pubmed: 11914310
Cochrane Database Syst Rev. 2016 Sep 27;9:CD003733
pubmed: 27673392
Ann Allergy. 1983 May;50(5):320-2
pubmed: 6846922
J Pediatr. 1997 Aug;131(2):278-83
pubmed: 9290616
Med Hypotheses. 1997 Jan;48(1):11-7
pubmed: 9049983
Ann Allergy. 1988 Aug;61(2):129-32
pubmed: 3400898
Blood. 1995 Jul 15;86(2):776-83
pubmed: 7606007
Thorax. 2005 Mar;60(3):206-10
pubmed: 15741436
Cochrane Database Syst Rev. 2003;(3):CD003733
pubmed: 12917983
Cochrane Database Syst Rev. 2012 Jul 11;(7):CD003733
pubmed: 22786487
Lancet. 2001 Mar 3;357(9257):680-3
pubmed: 11247552
Pediatr Pulmonol. 1999 Sep;28(3):205-16
pubmed: 10495338
J Clin Pathol. 1991 Jun;44(6):459-63
pubmed: 2066423
Br Med J (Clin Res Ed). 1982 Aug 28-Sep 4;285(6342):633-5
pubmed: 6819042
J Pediatr. 2001 Feb;138(2):188-92
pubmed: 11174615
N Engl J Med. 1994 Jun 9;330(23):1639-44
pubmed: 7993409
Cochrane Database Syst Rev. 2014 Aug 02;(8):CD003733
pubmed: 25086371
Pediatr Emerg Care. 2005 Feb;21(2):99-101
pubmed: 15699818
East Afr Med J. 1970 Aug;47(8):434-9
pubmed: 5479792