N-Substituted piperidine-3-carbohydrazide-hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta-amyloid inhibitory activity, and antioxidant capacity.
Humans
Butyrylcholinesterase
/ metabolism
Alzheimer Disease
/ drug therapy
Amyloid beta-Peptides
Acetylcholinesterase
/ metabolism
Antioxidants
/ chemistry
Hydrazones
Reactive Oxygen Species
Kinetics
Structure-Activity Relationship
Cholinesterase Inhibitors
/ chemistry
Piperidines
/ pharmacology
Molecular Docking Simulation
Molecular Structure
acetylcholinesterase inhibitory
antioxidant activity
butyrylcholinesterase inhibitory
kinetic study
molecular modeling
thioflavin T test
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
revised:
01
11
2022
received:
03
10
2022
accepted:
03
11
2022
pubmed:
4
12
2022
medline:
3
3
2023
entrez:
3
12
2022
Statut:
ppublish
Résumé
A series of piperidine-3-carbohydrazide-hydrazones bearing phenylethyl, phenylpropyl, and phenylbutyl substituents on piperidine nitrogen were designed and synthesized as cholinesterase (ChE) inhibitors. The title compounds were screened for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory activities and antioxidant capacities, and the active ones for Aβ
Identifiants
pubmed: 36461719
doi: 10.1002/ardp.202200519
doi:
Substances chimiques
Butyrylcholinesterase
EC 3.1.1.8
Amyloid beta-Peptides
0
Acetylcholinesterase
EC 3.1.1.7
carbohydrazide
W8V7FYY4WH
Antioxidants
0
Hydrazones
0
Reactive Oxygen Species
0
Cholinesterase Inhibitors
0
Piperidines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200519Subventions
Organisme : Türkiye Bilimsel ve Teknolojik Arastirma Kurumu
ID : 214S083
Informations de copyright
© 2022 Deutsche Pharmazeutische Gesellschaft.
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