Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 12 2022
15 12 2022
Historique:
received:
22
08
2022
accepted:
20
10
2022
pmc-release:
15
12
2023
entrez:
5
12
2022
pubmed:
6
12
2022
medline:
14
1
2023
Statut:
ppublish
Résumé
CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine.
Identifiants
pubmed: 36469843
pii: 237291
doi: 10.4049/jimmunol.2200578
pmc: PMC9886274
mid: NIHMS1844691
doi:
Substances chimiques
Receptors, CCR
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2281-2286Subventions
Organisme : NIAID NIH HHS
ID : R01 AI105265
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142382
Pays : United States
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
Références
Eur J Immunol. 2018 Jun;48(6):950-964
pubmed: 29500823
J Neurovirol. 2004 Jun;10(3):152-62
pubmed: 15204920
Annu Rev Immunol. 2014;32:659-702
pubmed: 24655300
Nat Rev Immunol. 2009 Mar;9(3):153-61
pubmed: 19240755
Nat Rev Neurosci. 2007 Oct;8(10):755-65
pubmed: 17882253
Obstet Gynecol Surv. 2002 Apr;57(4):245-56
pubmed: 11961482
J Clin Virol. 2009 Dec;46 Suppl 4:S6-10
pubmed: 19800841
Immunity. 2011 Apr 22;34(4):602-15
pubmed: 21511186
Arch Ophthalmol. 2006 May;124(5):743
pubmed: 16682601
J Immunol. 2008 Aug 1;181(3):2111-23
pubmed: 18641350
Eur J Immunol. 2004 Oct;34(10):2720-9
pubmed: 15368288
J Virol. 2004 Feb;78(3):1473-87
pubmed: 14722303
J Exp Med. 2008 Feb 18;205(2):423-35
pubmed: 18268036
Pathogens. 2021 Aug 21;10(8):
pubmed: 34451526
Microorganisms. 2020 Jan 25;8(2):
pubmed: 31991822
Immunity. 2004 Oct;21(4):527-38
pubmed: 15485630
Nutrients. 2016 Jun 13;8(6):
pubmed: 27304965
J Immunol. 2016 Feb 15;196(4):1604-16
pubmed: 26764033
Viruses. 2021 Jun 04;13(6):
pubmed: 34200083
Eur J Pediatr. 2006 Nov;165(11):773-8
pubmed: 16835757
J Pediatr. 2005 Jun;146(6):817-23
pubmed: 15973325
Rev Med Virol. 2005 Sep-Oct;15(5):327-45
pubmed: 16100703
Immunol Cell Biol. 2002 Apr;80(2):156-63
pubmed: 11940116
Arch Virol. 1979;62(1):1-29
pubmed: 231945
Ultrasound Obstet Gynecol. 2016 May;47(5):600-7
pubmed: 25412951
Mucosal Immunol. 2008 Jan;1(1):38-48
pubmed: 19079159
J Neuropathol Exp Neurol. 2014 Feb;73(2):143-58
pubmed: 24423639
J Virol. 2008 Dec;82(24):12172-80
pubmed: 18842707