Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.
Homeostasis
Hormones
Immunity
Maternal sepsis
Maternity
Metabolism
Pregnancy
Sepsis
Set-point change
Setpoint
Vaccines
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
19
07
2022
revised:
30
09
2022
accepted:
17
10
2022
pubmed:
6
12
2022
medline:
21
12
2022
entrez:
5
12
2022
Statut:
ppublish
Résumé
Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cellular, and molecular systems-level in the context of sepsis. We identify distinct immune phases in pregnancy delineated by placental hormone-driven changes in homeostasis setpoints of the immune and metabolic systems that subtly mirrors changes observed in sepsis. We propose that pregnancy immune-metabolic setpoint changes impact feedback thresholds that increase risk for a maladapted host-response to infection and thus act as a stepping-stone to sepsis. Defining maternal immune-metabolic setpoint changes is not only vital for tailoring the right diagnostic tools for early management of maternal sepsis but will facilitate an unravelling of the pathophysiological pathways that predispose an individual to sepsis.
Identifiants
pubmed: 36470829
pii: S2352-3964(22)00519-9
doi: 10.1016/j.ebiom.2022.104337
pmc: PMC9782817
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104337Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of interests P.G is a member of the development board for Sepsis Trust UK with no cash incentive.
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