Growth Hormone Administration to Improve Reproductive Outcomes in Women with Recurrent Implantation Failure (RIF): a Systematic Review.
Growth hormone
Meta-analysis
Recurrent implantation failure
Systematic review
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
16
08
2022
accepted:
05
11
2022
medline:
1
6
2023
pubmed:
6
12
2022
entrez:
5
12
2022
Statut:
ppublish
Résumé
Recurrent implantation failure (RIF) has been used to describe embryos' failure to implant following IVF, arising concerns about the importance of its treatment. Growth hormone (GH) has been studied as one of the possible co-interventions. Our updated review evaluated GH intervention vs. no intervention from randomized controlled trials (RCTs) in RIF patients. Electronic searches on The Menstrual Disorders and Subfertility Group (MDSG), The Cochrane Central Register for Clinical Trials, PubMed MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS, and Google Scholar up to August 2021 identified 2 RCTs and compiled with the above inclusion criteria. The risk of bias (ROB) and the quality of evidence were assessed according to the Cochrane Collaboration tool and GRADE group guidelines. Meta-analysis found higher rates of clinical pregnancy (OR: 4.97 CI 95% 2.05 to 12.05), live birth (OR: 5.13 CI 95% 2.03 to 12.91), and implantation (OR: 3.88 CI 95% 1.91 to 7.88) when compared GH to no intervention; as well as an increased endometrial thickness (mean difference: 1.14 CI 95% -0.0 to 2.28). However, this review cannot provide a strong recommendation due to the quality of evidence rated as "very low quality of evidence" in all the outcomes for reasons such as methodology issues, heterogeneity, intervention regimen, and limited sample sizes with large confidence intervals and a low number of events. We emphasize the importance of upcoming high-quality research and the need for consensus concepts in RIF patients, which may be a minority; it is still one of the highest impacts on life quality.
Identifiants
pubmed: 36471218
doi: 10.1007/s43032-022-01124-5
pii: 10.1007/s43032-022-01124-5
doi:
Substances chimiques
Growth Hormone
9002-72-6
Types de publication
Systematic Review
Meta-Analysis
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1712-1723Informations de copyright
© 2022. The Author(s), under exclusive licence to Society for Reproductive Investigation.
Références
Ochoa-Bernal M, Fazleabas A. Physiologic events of embryo implantation and decidualization in human and non-human primates. Int J Mol Sci. 2020;21(6):1973–94.
pubmed: 32183093
pmcid: 7139778
doi: 10.3390/ijms21061973
Robins JC. Implantation: trophoblast-endometrial interactions. Semin Reprod Med. 2016;34(1):3–4.
pubmed: 26731466
doi: 10.1055/s-0035-1570034
Kim S, Kim J. A review of mechanisms of implantation. Dev Reprod. 2017;21(4):351–9.
pubmed: 29359200
pmcid: 5769129
doi: 10.12717/DR.2017.21.4.351
Vitiello D, Patrizio P. Implantation and early embryonic development: implications for pregnancy. Semin Perinatol. 2007;31(4):204–7.
pubmed: 17825673
doi: 10.1053/j.semperi.2007.05.006
Teh WT, McBain J, Rogers P. What is the contribution of embryo-endometrial asynchrony to implantation failure? J Assist Reprod Genet. 2016;33(11):1419–30.
pubmed: 27480540
pmcid: 5125144
doi: 10.1007/s10815-016-0773-6
Sebastian-León P, Garrido N, Remohí J, Pellicer A, Diaz-Gimeno P. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod. 2018;33:626–35.
pubmed: 29452422
doi: 10.1093/humrep/dey023
Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong R, Sallam H, Li TC. Recurrent implantation failure: definition and management. Reprod BioMed Online. 2014;28(1):14–38.
pubmed: 24269084
doi: 10.1016/j.rbmo.2013.08.011
Zeyneloglu HB, Onalan G. Remedies for recurrent implantation failure. Semin Reprod Med. 2014;32(4):297–305.
pubmed: 24919029
doi: 10.1055/s-0034-1375182
Rinehart J. Recurrent implantation failure: definition. J Assist Reprod Genet. 2007;24(7):284–7.
pubmed: 17674185
pmcid: 3455006
doi: 10.1007/s10815-007-9147-4
Zohni KM, Gat I, Librach C. Recurrent implantation failure: a comprehensive review. Minerva Ginecol. 2016;68(6):653–67.
pubmed: 26982235
Somigliana E, Vigano P, Busnelli A, Paffoni A, Vegetti W, Vercellini P. Repeated implantation failure at the crossroad between statistics, clinics and over-diagnosis. Reprod Biomed Online. 2018;36(1):32–8.
pubmed: 29102484
doi: 10.1016/j.rbmo.2017.09.012
Thornhill AR, deDie-Smulders CE, Geraedts JP, Harper JC, Harton GL, Lavery SA, Moutou C, Robinson MD, Schmutzler AG, Scriven PN, et al. ESHRE PGD Consortium ‘Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS).’ Hum Reprod. 2005;20:35–48.
pubmed: 15539444
doi: 10.1093/humrep/deh579
Bashiri A, Halper KI, Orvieto R. Recurrent implantation failure-update overview on etiology, diagnosis, treatment and future directions. Reprod Biol Endocrinol. 2018;16(1):121–39.
pubmed: 30518389
pmcid: 6282265
doi: 10.1186/s12958-018-0414-2
Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertil Steril. 2019;111(4):618–28.
pubmed: 30929719
doi: 10.1016/j.fertnstert.2019.02.011
Magdi Y, El-Damen A, Fathi AM, et al. Revisiting the management of recurrent implantation failure through freeze-all policy. Fertil Steril. 2017;108(1):72–7.
pubmed: 28579406
doi: 10.1016/j.fertnstert.2017.04.020
Moustafa S, Young SL. Diagnostic and therapeutic options in recurrent implantation failure [version 1; peer review: 2 approved]. F1000Research 2020; 9(F1000 Faculty Rev):208–217.
Altmäe S, Reimand JR, Hovatta O, Zhang P, Kere J, Laisk T, Saare M, Peters M, Vilo J, Stavreus-Evers A, et al. Research resource: interactome of human embryo implantation: identification of gene expression pathways, regulation, and integrated regulatory networks. Mol Endocrinol. 2012;26:203–17.
pubmed: 22074951
doi: 10.1210/me.2011-1196
Lessey B, Young S. What exactly is endometrial receptivity? Fertil Steril. 2019;111(4):611–7.
pubmed: 30929718
doi: 10.1016/j.fertnstert.2019.02.009
Dvořan M, Vodička J, Dostál J, Hajdúch M, Džubák P, Pešková M, Pilka R. Implantation and diagnostics of endometrial receptivity Implantace a diagnostika receptivity endometria. Ceska Gynekol. 2018;83(4):291–8.
pubmed: 30441961
Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F, Simon C. Understanding and improving endometrial receptivity. Curr Opin Obstet Gynecol. 2015;27(3):187–92.
pubmed: 25827647
doi: 10.1097/GCO.0000000000000173
Paulson RJ. Introduction: endometrial receptivity: evaluation, induction and inhibition. Fertil Steril. 2019;111(4):609–10.
pubmed: 30929717
doi: 10.1016/j.fertnstert.2019.02.029
Cailleau J, Vermeire S, Verhoeven G. Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells. Mol Cell Endocrinol. 1990;69:79–89.
pubmed: 2157618
doi: 10.1016/0303-7207(90)90091-L
Altmäe S, Aghajanova L. Growth hormone and endometrial receptivity. Front Endocrinol (Lausanne). 2019;10:653–64.
pubmed: 31616379
doi: 10.3389/fendo.2019.00653
Liu FT, Wu Z, Yan J, Norman RJ, Li R. The potential role of growth hormone on the endometrium in assisted reproductive technology. Front Endocrinol (Lausanne). 2020;11:49–57.
pubmed: 32117072
doi: 10.3389/fendo.2020.00049
Cui N, Li AM, Luo ZY, Zhao ZM, Xu YM, Zhang J, Yang AM, Wang LL, Hao GM, Gao BL. Effects of growth hormone on pregnancy rates of patients with thin endometrium [published correction appears in J Endocrinol Invest. 2018 Aug 20]. J Endocrinol Invest. 2019;42(1):27–35.
Sbracia M, Scarpellini F, Poverini R, Alò PL, Rossi G, Di Tondo U. Immunohistochemical localization of the growth hormone in human endometrium and decidua. Am J Reprod Immunol. 2004;51:112–6.
pubmed: 14748836
doi: 10.1046/j.8755-8920.2003.00127.x
Ferrara N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2009;29(6):789–91.
pubmed: 19164810
doi: 10.1161/ATVBAHA.108.179663
Korompelis P, Piperi C, Adamopoulos C, Dalagiorgou G, Korkolopoulou P, Sepsa A, Antsaklis A, Papavassiliou AG. Expression of vascular endothelial factor-A, gelatinases (MMP-2, MMP-9) and TIMP-1 in uterine leiomyomas. Clin Chem Lab Med. 2015;53(9):1415–24.
pubmed: 25470608
doi: 10.1515/cclm-2014-0798
Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J Clin Endocrinol Metab. 1999;84(6):2245–8.
pubmed: 10372740
doi: 10.1210/jcem.84.6.5886
Sun ZG, Lian F, Jia Q, Sun JL, Li TT, Guo Y, Zhang JW, Zhang N, Liu H, Wang LH. Effects of Er’zhi Tiangui Granule on sequential expressions of integrin β 3 and its ligand osteopontin in mouse endometrium during controlled ovarian hyperstimulation. Chin J Integr Med. 2012;18(11):846–9.
pubmed: 23086489
doi: 10.1007/s11655-012-1273-7
Tei C, Maruyama T, Kuji N, Miyazaki T, Mikami M, Yoshimura Y. Reduced expression of αvβ3 integrin in the endometrium of unexplained infertility patients with recurrent IVF-ET failures: improvement by danazol treatment. J Assist Reprod Genet. 2003;20:13–20.
pubmed: 12645863
pmcid: 3455802
doi: 10.1023/A:1021254620888
Lessey BA, Castelbaum AJ. Integrins and implantation in the human. Rev Endocr Metab Disord. 2002;3(2):107–17.
pubmed: 12007287
doi: 10.1023/A:1015450727580
Kaneko Y, Day ML, Murphy CR. Integrin β3 in rat blastocysts and epithelial cells is essential for implantation in vitro: studies with Ishikawa cells and small interfering RNA transfection. Hum Reprod. 2011;26(7):1665–74.
pubmed: 21531996
doi: 10.1093/humrep/der128
Taketani T, Yamagata Y, Takasaki A, Matsuoka A, Tamura H, Sugino N. Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells. Fertil Steril. 2008;90:744–8.
pubmed: 17953960
doi: 10.1016/j.fertnstert.2007.07.1304
Schams D, Berisha B, Kosmann M, Einspanier R, Amselgruber WM. Possible role of growth hormone, IGFs, and IGF-binding proteins in the regulation of ovarian function in large farm animals. Domest Anim Endocrinol. 1999;17:279–85.
pubmed: 10527130
doi: 10.1016/S0739-7240(99)00044-2
Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. The insulin-related ovarian regulatory systemin health and disease. Endocr Rev. 1999;20:535–82.
pubmed: 10453357
doi: 10.1210/edrv.20.4.0374
Eftekhar M, Aflatoonian A, Mohammadian F, Eftekhar T. Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology. Arch Gynecol Obstet. 2013;287:1017–21.
pubmed: 23208461
doi: 10.1007/s00404-012-2655-1
Dakhly DMR, Bayoumi YA, Gad Allah SH. Which is the best IVF/ICSI protocol to be used in poor responders receiving growth hormone as an adjuvant treatment? A prospective randomized trial Gynecol Endocrinol. 2016;32:116–9.
pubmed: 26416521
doi: 10.3109/09513590.2015.1092136
Kucuk T, Kozinoglu H, Kaba A. Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial. J Assist Reprod Genet. 2008;25:123–7.
pubmed: 18392675
pmcid: 2582075
doi: 10.1007/s10815-008-9212-7
Dakhly DMR, Bassiouny YA, Bayoumi YA, Hassan MA, Gouda HM, Hassan AA. The addition of growth hormone adjuvant therapy to the long down regulation protocol in poor responders undergoing in vitro fertilization: randomized control trial. Eur J Obstet Gynecol Reprod Biol. 2018;228:161–5.
pubmed: 29957401
doi: 10.1016/j.ejogrb.2018.06.035
Wu H, Li L, Li M, Yuan H. Effect of growth hormone on the endometrial and endometrial blood flow in forzen thawed embryo tranfer. J Reprod Med. 2013;12:914–7.
Yu H, Gao S, Tang H, Chen H, Deng Z, Yang L, et al. Growth hormone intrauterine perfusion combined with replacement cycle in the treatment of non-response thin endometrium: report of 5 cases. Int J Clin Exp Med. 2016;9:11982–9.
Yang JY, Li H, Lu N, Li L, Sun XX. Influence of growth hormone supplementation in patients with thin endometrium undergoing frozen embryo transfer. Reprod Dev Med. 2019;3:49–53.
doi: 10.4103/2096-2924.255983
Lan KC, Lin PY, Chang YC, Chen YJ, Tsai YR, Mohamed ISI, Kang HY. Growth hormone supplementation may improve the pregnancy rate and endometrial receptivity among women aged more than 40 years undergoing in vitro fertilization. Biomed J. 2019;42(6):411–6.
pubmed: 31948605
pmcid: 6962760
doi: 10.1016/j.bj.2019.05.003
Choe SA, Kim MJ, Lee HJ, Kim J, Chang EM, Kim JW, Park HM, Lyu SW, Lee WS, Yoon TK, et al. Increased proportion of mature oocytes with sustained-release growth hormone treatment in poor responders: a prospective randomized controlled study. Arch Gynecol Obstet. 2018;297:791–6.
pubmed: 29264647
doi: 10.1007/s00404-017-4613-4
Coughlan C, Walters S, Ledger W, Li TC. A comparison of psychological stress among women with and without reproductive failure. Int J Gynaecol Obstet. 2014;124(2):143–7.
pubmed: 24290538
doi: 10.1016/j.ijgo.2013.08.006
Gameiro S, Boivin J, Peronace L, Verhaak CM. Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment. Hum Reprod Update. 2012;18(6):652–69.
pubmed: 22869759
pmcid: 3461967
doi: 10.1093/humupd/dms031
Gameiro S, Verhaak CM, Kremer JA, Boivin J. Why we should talk about compliance with assisted reproductive technologies (ART): a systematic review and meta-analysis of ART compliance rates. Hum Reprod Update. 2013;19(2):124–35.
pubmed: 23178304
doi: 10.1093/humupd/dms045
Busnelli A, Reschini M, Cardellicchio L, Vegetti W, Somigliana E, Vercellini P. How common is real repeated implantation failure? An indirect estimate of the prevalence. Reprod Biomed Online. 2020;40(1):91–7.
pubmed: 31924493
doi: 10.1016/j.rbmo.2019.10.014
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, 2019. Available from www.training.cochrane.org/handbook .
Andrews JC, Schünemann HJ, Oxman AD, Pottie K, Meerpohl JJ, Coello PA, et al. GRADE guidelines: 15 Going from evidence to recommendation-determinants of a recommendation’s direction and strength. J Clin Epidemiol. 2013;66(7):726–35.
pubmed: 23570745
doi: 10.1016/j.jclinepi.2013.02.003
Santesso N, Glenton C, Dahm P, Garner P, Akl EA, Alper B, Brignardello-Petersen R, Carrasco-Labra A, De Beer H, Hultcrantz M, et al. GRADE Working Group. GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions. J Clin Epidemiol. 2020;119:126–35.
pubmed: 31711912
doi: 10.1016/j.jclinepi.2019.10.014
Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ; GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–6.
doi: 10.1136/bmj.39489.470347.AD
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6(7):e1000097.
Altmäe S, Mendoza-Tesarik R, Mendoza C, Mendoza N, Cucinelli F, Tesarik J. Effect of growth hormone on uterine receptivity in women with repeated implantation failure in an oocyte donation program: a randomized controlled trial. J Endocr Soc. 2017;2(1):96–105.
pubmed: 29379897
pmcid: 5779111
doi: 10.1210/js.2017-00359
Chen Y, Liu F, Nong Y, Ruan J, Guo Q, Luo M, et al. Clinical efficacy and mechanism of growth hormone action in patients experiencing repeat implantation failure. Can J Physiol Pharmacol. 2018;96(9):929–32.
pubmed: 29726701
doi: 10.1139/cjpp-2017-0786
CORRIGENDUM FOR "Effect of growth hormone on uterine receptivity in women with repeated implantation failure in an oocyte donation program: a randomized controlled trial". J Endocr Soc. 2018;2(2):133.
Ethics Committee of the American Society for Reproductive Medicine. Oocyte or embryo donation to women of advanced age: a committee opinion. Fertil Steril. 2013;100(2):337–40.
doi: 10.1016/j.fertnstert.2013.02.030
Ethics Committee of the American Society for Reproductive Medicine. Fertility treatment when the prognosis is very poor or futile: an Ethics Committee opinion. Fertil Steril. 2019;111(4):659–63.
doi: 10.1016/j.fertnstert.2019.01.033
MacArthur T, Bachmann G, Ayers C. Menopausal women requesting egg/embryo donation: examining health screening guidelines for assisted reproductive technology. Menopause. 2016;23(7):799–802.
pubmed: 27187010
doi: 10.1097/GME.0000000000000622
Somigliana E, Paffoni A, Busnelli A, Filippi F, Pagliardini L, Vigano P, Vercellini P. Age-related infertility and unexplained infertility: an intricate clinical dilemma. Hum Reprod. 2016;31(7):1390–6.
pubmed: 27060173
doi: 10.1093/humrep/dew066
Regan SLP, Knight PG, Yovich JL, Arfuso F, Dharmarajan A. Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. Fertil Steril. 2018;110(7):1298–310.
pubmed: 30503129
doi: 10.1016/j.fertnstert.2018.08.018
Yu X, Ruan J, He LP, Hu W, Xu Q, Tang J, Jiang J, Han J, Peng YF. Efficacy of growth hormone supplementation with gonadotrophins in vitro fertilization for poor ovarian responders: an updated meta-analysis. Int J Clin Exp Med. 2015;8(4):4954–67.
pubmed: 26131068
pmcid: 4483949
Hart RJ. Use of growth hormone in the IVF treatment of women with poor ovarian reserve. Front Endocrinol (Lausanne). 2019;10:500–7.
pubmed: 31396160
doi: 10.3389/fendo.2019.00500
Hart RJ, Rombauts L, Norman RJ. Growth hormone in IVF cycles: any hope? Curr Opin Obstet Gynecol. 2017;29(3):119–25.
pubmed: 28306560
doi: 10.1097/GCO.0000000000000360
Duffy JM, Ahmad G, Mohiyiddeen L, Nardo LG, Watson A. Growth hormone for in vitro fertilization. Cochrane Database Syst Rev. 2010;2010(1):CD000099.
Zhang Y, Zhang C, Shu J, Guo J, Chang HM, Leung PCK, Sheng JZ, Huang H. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26(2):247–63.
pubmed: 32045470
doi: 10.1093/humupd/dmz046
Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ; GRADE Working Group. What is "quality of evidence" and why is it important to clinicians? BMJ. 2008;336(7651):995–998.
Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, Schünemann HJ. GRADE Working Group. Going from evidence to recommendations BMJ. 2008;336(7652):1049–51.
pubmed: 18467413