Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the
C4b binding protein
Plasmodium
circumsporozoite protein
complement evasion
sporozoites
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
09
2022
accepted:
02
11
2022
entrez:
8
12
2022
pubmed:
9
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
The complement system is considered the first line of defense against pathogens. Hijacking complement regulators from blood is a common evasion tactic of pathogens to inhibit complement activation on their surfaces. Here, we report hijacking of the complement C4b-binding protein (C4bp), the regulator of the classical and lectin pathways of complement activation, by the sporozoite (SPZ) stage of the
Identifiants
pubmed: 36479121
doi: 10.3389/fimmu.2022.1051161
pmc: PMC9720182
doi:
Substances chimiques
Complement C4b-Binding Protein
0
Complement Inactivating Agents
0
Peptides
0
Vaccines
0
C4BPA protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1051161Informations de copyright
Copyright © 2022 Khattab, Rezola, Barroso, Kyrklund, Pihlajamaa, Freitag, van Gemert, Bousema, Permi, Turunen, Sauerwein, Luty and Meri.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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