Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives.
Antitumor
Brassinolide
Brassinosteroid
Cancer
Epibrassinolide
SAR
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
16
08
2022
revised:
24
10
2022
accepted:
02
12
2022
pubmed:
9
12
2022
medline:
12
1
2023
entrez:
8
12
2022
Statut:
ppublish
Résumé
Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure-activity relationship based on the available information.
Identifiants
pubmed: 36481216
pii: S0039-128X(22)00192-1
doi: 10.1016/j.steroids.2022.109153
pii:
doi:
Substances chimiques
Brassinosteroids
0
Plant Growth Regulators
0
Steroids, Heterocyclic
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109153Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.