Harmonica consensus, controversies, and future directions in radiotherapy for pediatric Wilms tumors.
HARMONICA
Wilms tumor
pediatric renal tumors
radiotherapy
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
16
10
2022
received:
21
08
2022
accepted:
18
10
2022
medline:
26
4
2023
pubmed:
10
12
2022
entrez:
9
12
2022
Statut:
ppublish
Résumé
Radiotherapy (RT) is essential for multimodality treatment of pediatric renal tumors, particularly in higher-risk and metastatic disease. Despite decades of use, particularly for Wilms tumor, there remain controversies regarding RT indications, timing, dose, and targets. To align global management, we address these issues in this international HARMONIsation and CollAboration (HARMONICA) project. There are multiple knowledge gaps and opportunities for future research including: (1) utilization of advanced RT technologies, including intensity-modulated RT, proton beam therapy, combined with image-guided RT to reduce target volumes; (2) impact of molecular biomarkers including loss of heterozygosity at 1p, 16q, and 1q gain on RT indications; (3) mitigation of reproductive toxicity following RT; (4) promotion of RT late effects research; and (5) support to overcome challenges in RT utilization in low- and middle-income countries where 90% of the world's children reside. Here, we outline current status and future directions for RT in pediatric renal tumors.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e30090Informations de copyright
© 2022 Wiley Periodicals LLC.
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