Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly.
acromegaly
gene expression
growth hormone
neuroendocrine pituitary tumors
somatotropinoma
transcriptome
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
30 Nov 2022
30 Nov 2022
Historique:
received:
19
10
2022
revised:
22
11
2022
accepted:
25
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Acromegaly results from growth hormone hypersecretion, predominantly caused by a somatotroph pituitary neuroendocrine tumor (PitNET). Acromegaly-causing tumors are histologically diverse. Our aim was to determine transcriptomic profiles of various somatotroph PitNETs and to evaluate clinical implication of differential gene expression. A total of 48 tumors were subjected to RNA sequencing, while expression of selected genes was assessed in 134 tumors with qRT-PCR. Whole-transcriptome analysis revealed three transcriptomic groups of somatotroph PitNETs. They differ in expression of numerous genes including those involved in growth hormone secretion and known prognostic genes. Transcriptomic subgroups can be distinguished by determining the expression of marker genes. Analysis of the entire cohort of patients confirmed differences between molecular subtypes of tumors. Transcriptomic group 1 includes ~20% of acromegaly patients with
Identifiants
pubmed: 36497102
pii: cells11233846
doi: 10.3390/cells11233846
pmc: PMC9738119
pii:
doi:
Substances chimiques
Growth Hormone
9002-72-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Maria Sklodowska-Curie National Research Institute of Oncology
ID : SN/GW04/2020
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