Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females.

Animals Female Male Mice Alzheimer Disease / genetics Amyloid beta-Peptides / metabolism Extracellular Signal-Regulated MAP Kinases / metabolism Hippocampus / metabolism Protein Tyrosine Phosphatases / genetics Learning
Alzheimer’s disease disease-associated microglia dual-specificity protein phosphatase 4 mitogen-activated protein kinase neuroinflammation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
01 Dec 2022
Historique:
received: 10 08 2022
revised: 28 11 2022
accepted: 29 11 2022
entrez: 11 12 2022
pubmed: 12 12 2022
medline: 15 12 2022
Statut: epublish

Résumé

Recent multiscale network analyses of banked brains from subjects who died of late-onset sporadic Alzheimer's disease converged on

Identifiants

DOI: 10.3390/cells11233880 PMID: 36497141 PMC: PMC9737364
pubmed: 36497141
pii: cells11233880
doi: 10.3390/cells11233880
pmc: PMC9737364
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24
MKP2 protein, mouse EC 3.1.3.48
Protein Tyrosine Phosphatases EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : RF1AG054014
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057440
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK117504
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054014
Pays : United States
Organisme : NIA NIH HHS
ID : U01AG046170
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117504
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059319
Pays : United States
Organisme : NIA NIH HHS
ID : RF1AG057440
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG062355
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062355
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057907
Pays : United States
Organisme : NIA NIH HHS
ID : RF1AG062661
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062661
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046170
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG057907
Pays : United States

Références

J Alzheimers Dis. 2019;70(4):1259-1274
pubmed: 31322556
J Neuroinflammation. 2021 Mar 17;18(1):74
pubmed: 33731174
J Neuroimmunol. 2002 May;126(1-2):50-7
pubmed: 12020956
EMBO Mol Med. 2011 May;3(5):291-302
pubmed: 21500352
Neuromolecular Med. 2005;7(3):255-64
pubmed: 16247185
Int J Mol Sci. 2020 Aug 06;21(16):
pubmed: 32781522
IUBMB Life. 2004 Jun;56(6):349-54
pubmed: 15370883
Mol Neurodegener. 2020 Nov 12;15(1):69
pubmed: 33183335
Neurosci Lett. 1988 Sep 12;91(3):259-64
pubmed: 2972943
J Biol Chem. 2018 Nov 30;293(48):18434-18443
pubmed: 30315100
Mol Neurodegener. 2020 Jan 10;15(1):4
pubmed: 31924226
Trends Endocrinol Metab. 1996 Sep;7(7):233-9
pubmed: 18406753
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
FASEB J. 1999 Jan;13(1):63-8
pubmed: 9872930
J Neuroinflammation. 2014 Jul 25;11:127
pubmed: 25062954
Nat Neurosci. 2022 Feb;25(2):213-225
pubmed: 35115731
J Neuroinflammation. 2012 Aug 16;9:199
pubmed: 22898493
FEBS J. 2013 Jan;280(2):489-504
pubmed: 22812510
Neuron. 2021 Jan 20;109(2):257-272.e14
pubmed: 33238137
Sci Rep. 2018 Mar 9;8(1):4282
pubmed: 29523845
Front Cell Neurosci. 2022 Jul 05;16:939830
pubmed: 35875349
Alzheimers Dement. 2013 Mar;9(2):208-45
pubmed: 23507120
Nature. 1992 Dec 17;360(6405):672-4
pubmed: 1465129
Ann Neurol. 2018 Jul;84(1):78-88
pubmed: 29908079
J Biol Chem. 2003 Mar 28;278(13):11138-44
pubmed: 12540838
FASEB J. 2006 Jan;20(1):157-9
pubmed: 16293708
Int J Mol Sci. 2020 Mar 28;21(7):
pubmed: 32231094
Nat Neurosci. 2010 Nov;13(11):1373-9
pubmed: 20935641
Am J Pathol. 2009 Nov;175(5):2076-88
pubmed: 19808651
Nat Neurosci. 2020 Feb;23(2):167-171
pubmed: 31873194
J Neurosci. 2015 Jul 15;35(28):10343-56
pubmed: 26180209
J Biol Chem. 2021 Jan-Jun;296:100489
pubmed: 33662398
J Neurochem. 2008 Oct;107(1):73-85
pubmed: 18643872
Oncogene. 2004 Apr 12;23(16):2838-49
pubmed: 15077147
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
PLoS Pathog. 2010 Nov 11;6(11):e1001192
pubmed: 21085614
Nat Med. 2017 Sep;23(9):1102-1111
pubmed: 28825715
Nat Commun. 2020 Aug 7;11(1):3942
pubmed: 32770063
J Biol Chem. 1995 Jun 16;270(24):14587-96
pubmed: 7782322
FASEB J. 2014 Feb;28(2):978-97
pubmed: 24165480
Mol Psychiatry. 2018 Jul;23(7):1632-1642
pubmed: 29158577
Sci Rep. 2018 Jan 24;8(1):1550
pubmed: 29367720
Oncogene. 2007 May 14;26(22):3240-53
pubmed: 17496919
J Neurosci. 2008 Sep 24;28(39):9857-69
pubmed: 18815270
Prog Neurobiol. 2021 Mar;198:101906
pubmed: 32905807
Biochem Biophys Res Commun. 2015 Nov 13;467(2):254-60
pubmed: 26435497
Cell Death Dis. 2020 Jun 8;11(6):440
pubmed: 32514180
Mol Neurodegener. 2014 Sep 11;9:33
pubmed: 25213090
J Immunol. 2013 Mar 1;190(5):2241-51
pubmed: 23365075
Int J Mol Sci. 2019 Apr 23;20(8):
pubmed: 31018603
J Biol Chem. 1996 Feb 23;271(8):4319-26
pubmed: 8626780
Sci Rep. 2020 Feb 21;10(1):3153
pubmed: 32081950
Neurochem Res. 2013 Jan;38(1):218-25
pubmed: 23086473
Front Neurol. 2021 May 14;12:654850
pubmed: 34054698
Biochem Insights. 2013 Nov 21;6:1-10
pubmed: 25210460
Sci Rep. 2019 Feb 4;9(1):1393
pubmed: 30718543
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
J Comp Physiol Psychol. 1979 Feb;93(1):74-104
pubmed: 221551
J Neurosci. 2016 Feb 24;36(8):2348-54
pubmed: 26911683
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
Pharmacol Ther. 2013 Sep;139(3):313-26
pubmed: 23644076
J Immunol. 2010 May 1;184(9):5333-43
pubmed: 20368278
Sci Data. 2018 Sep 11;5:180185
pubmed: 30204156
Nature. 2020 Oct;586(7831):735-740
pubmed: 32879487
Science. 1993 Jan 22;259(5094):514-6
pubmed: 8424174
Int J Mol Sci. 2019 May 30;20(11):
pubmed: 31151270
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Neuroscientist. 2022 Mar 29;:10738584211070273
pubmed: 35348415
Transl Neurodegener. 2016 Apr 05;5:7
pubmed: 27054030
Front Pharmacol. 2022 May 10;13:833066
pubmed: 35620289
J Biol Chem. 1996 Mar 15;271(11):6497-501
pubmed: 8626452
Antioxidants (Basel). 2021 Nov 29;10(12):
pubmed: 34943020
Cell Biosci. 2012 Jul 09;2(1):24
pubmed: 22769588
Cells. 2020 Apr 29;9(5):
pubmed: 32365642
J Neurosci Res. 2002 Nov 1;70(3):462-73
pubmed: 12391607
J Neuroimmunol. 2002 Mar;124(1-2):83-92
pubmed: 11958825
J Neuroinflammation. 2005 Mar 11;2(1):9
pubmed: 15762998
Cell Signal. 2005 Jun;17(6):709-16
pubmed: 15722195
Stem Cells Dev. 2015 Mar 15;24(6):686-700
pubmed: 25397900
Nature. 1993 Jan 21;361(6409):260-3
pubmed: 7678698
J Neurosci. 2011 Dec 14;31(50):18237-50
pubmed: 22171029
Neurobiol Aging. 1988 Jul-Aug;9(4):339-49
pubmed: 3263583
JAMA. 1994 May 4;271(17):1316-7
pubmed: 8158809
J Neurosci Res. 2021 Jun;99(6):1704-1721
pubmed: 33729626
J Alzheimers Dis. 2022;85(2):755-778
pubmed: 34864660
J Mol Neurosci. 2019 Jul;68(3):504-509
pubmed: 30022437
Mol Psychiatry. 2019 Sep;24(9):1383-1397
pubmed: 30283031
J Clin Invest. 2020 Apr 1;130(4):1912-1930
pubmed: 31917687
Commun Biol. 2021 Jun 10;4(1):711
pubmed: 34112929
Acta Neuropathol Commun. 2016 Jul 11;4(1):72
pubmed: 27400725
Transl Psychiatry. 2017 Apr 18;7(4):e1094
pubmed: 28418403
Alzheimers Dement. 2020 Jun;16(6):896-907
pubmed: 32301581
EMBO J. 2021 Dec 15;40(24):e108662
pubmed: 34825707
Neurobiol Aging. 2009 Oct;30(10):1563-73
pubmed: 18255190
Mol Neurodegener. 2015 Jan 07;10:1
pubmed: 25567526
Mol Neurodegener. 2021 Nov 4;16(1):74
pubmed: 34736482
Brain Res. 2001 Mar 9;894(1):21-30
pubmed: 11245811
J Pharmacol Sci. 2021 Jul;146(3):169-181
pubmed: 34030799
Semin Cell Dev Biol. 2019 Oct;94:138-151
pubmed: 31112798
Nat Genet. 1998 Aug;19(4):357-60
pubmed: 9697696

Auteurs

Allen L Pan (AL)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Mickael Audrain (M)

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
ORCID: 0000-0001-9941-7380

Emmy Sakakibara (E)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Rajeev Joshi (R)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Xiaodong Zhu (X)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Qian Wang (Q)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Minghui Wang (M)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
ORCID: 0000-0001-9171-4962

Noam D Beckmann (ND)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Eric E Schadt (EE)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Sam Gandy (S)

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Department of Psychiatry and Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Bin Zhang (B)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Michelle E Ehrlich (ME)

Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Stephen R Salton (SR)

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
ORCID: 0000-0003-4087-8427

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Dual-Specificity Protein Phosphatase 4 (DUSP4)...
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Apprentissage › Dual-Specificity Protein Phosphatase 4 (DUSP4)...