Constipation Mitigation by Rhubarb Extract in Middle-Aged Adults Is Linked to Gut Microbiome Modulation: A Double-Blind Randomized Placebo-Controlled Trial.
Lachnospiraceae
butyrate-producing bacteria
constipation
microbiota
middle-aged
rhubarb
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Nov 2022
24 Nov 2022
Historique:
received:
07
10
2022
revised:
17
11
2022
accepted:
22
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
Gut microbiota alterations are intimately linked to chronic constipation upon aging. We investigated the role of targeted changes in the gut microbiota composition in the relief of constipation symptoms after rhubarb extract (RE) supplementation in middle-aged volunteers. Subjects (95% women, average 58 years old) were randomized to three groups treated with RE at two different doses determined by its content of rhein (supplementation of 12.5 mg and 25 mg per day) vs. placebo (maltodextrin) for 30 days. We demonstrated that daily oral supplementation of RE for 30 days was safe even at the higher dose. Stool frequency and consistency, and perceived change in transit problem, transit speed and difficulty in evacuating, investigated by validated questionnaires, were improved in both groups of RE-treated volunteers compared to placebo. Higher abundance of
Identifiants
pubmed: 36499011
pii: ijms232314685
doi: 10.3390/ijms232314685
pmc: PMC9738964
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Service Public de Wallonie
ID : 6918
Références
Eur Psychiatry. 2018 Sep;53:17-22
pubmed: 29859377
Mol Nutr Food Res. 2019 Dec;63(23):e1801187
pubmed: 31556210
Arch Phys Med Rehabil. 2015 Dec;96(12):2176-83
pubmed: 26301386
Am J Gastroenterol. 2012 Jan;107(1):18-25; quiz 26
pubmed: 21989145
Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):533-8
pubmed: 19535976
J Clin Med. 2021 Jan 04;10(1):
pubmed: 33406635
Physiol Genomics. 2014 Sep 15;46(18):679-86
pubmed: 25073603
Trials. 2018 Apr 27;19(1):256
pubmed: 29703235
Gastroenterology. 2013 May;144(5):967-77
pubmed: 23380084
Int J Mol Sci. 2019 Jan 20;20(2):
pubmed: 30669509
Front Med (Lausanne). 2019 Feb 12;6:19
pubmed: 30809523
J Neurogastroenterol Motil. 2011 Apr;17(2):140-7
pubmed: 21602990
Health Qual Life Outcomes. 2018 Dec 10;16(1):227
pubmed: 30526657
J Ethnopharmacol. 2021 Jan 10;264:113096
pubmed: 32693116
PLoS One. 2015 Dec 17;10(12):e0145106
pubmed: 26679505
J Pain Symptom Manage. 2009 Apr;37(4):737-45
pubmed: 18789639
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:188-196
pubmed: 31212236
Adv Exp Med Biol. 2021;1308:309-352
pubmed: 33861453
J Am Diet Assoc. 2009 Jun;109(6):1031-41
pubmed: 19465185
Mediators Inflamm. 2005 Aug 14;2005(3):175-9
pubmed: 16106105
J Pharm Pharmacol. 1986 May;38(5):369-73
pubmed: 2872313
Aliment Pharmacol Ther. 2010 May;31(9):938-49
pubmed: 20180788
PLoS One. 2020 Jul 17;15(7):e0235985
pubmed: 32678865
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 26990039
Gut. 1988 Sep;29(9):1180-7
pubmed: 3197991
Dig Liver Dis. 2005 Nov;37(11):838-49
pubmed: 16169298
Nutrients. 2020 Sep 24;12(10):
pubmed: 32987923
Appl Microbiol Biotechnol. 2022 Feb;106(4):1615-1631
pubmed: 35129656
Curr Microbiol. 2022 Feb 26;79(4):116
pubmed: 35218438
Best Pract Res Clin Gastroenterol. 2011 Feb;25(1):119-26
pubmed: 21382583
J Ethnopharmacol. 2014 Feb 27;152(1):190-200
pubmed: 24412547
Scand J Gastroenterol. 1997 Sep;32(9):920-4
pubmed: 9299672
Microorganisms. 2020 Apr 15;8(4):
pubmed: 32326636
Neurogastroenterol Motil. 2021 Jun;33(6):e14050
pubmed: 33263938
J Clin Gastroenterol. 2021 Jul 1;55(6):512-519
pubmed: 32569031