Are There Differences in Inflammatory and Fibrotic Pathways between IPAF, CTD-ILDs, and IIPs? A Single-Center Pilot Study.
CTD-ILDs
IIPs
IPAF
bronchoalveolar lavage
interstitial lung disease
interstitial pneumonia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Dec 2022
02 Dec 2022
Historique:
received:
27
10
2022
revised:
26
11
2022
accepted:
29
11
2022
entrez:
11
12
2022
pubmed:
12
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
In this pilot study, we aim to determine differences in pathogenetic pathways between interstitial pneumonia with autoimmune features (IPAF), connective-tissue-disease-associated interstitial lung diseases (CTD-ILDs), and idiopathic interstitial pneumonias (IIPs). Forty participants were recruited: 9 with IPAF, 15 with CTD-ILDs, and 16 with IIPs. Concentration of transforming growth factor beta (TGF-β1), surfactant proteins A and D (SP-A, SP-D), interleukin 8 (IL-8), and chemokine 1 (CXCL1) were assessed with ELISA assay in bronchoalveolar lavage (BAL) fluid. We revealed that IL-8 and TGF-β1 concentrations were significantly lower in the IPAF group than in the CTD-ILD group (
Identifiants
pubmed: 36499525
pii: ijms232315205
doi: 10.3390/ijms232315205
pmc: PMC9738037
pii:
doi:
Substances chimiques
Interleukin-8
0
Pulmonary Surfactant-Associated Protein D
0
Transforming Growth Factor beta1
0
Banques de données
ClinicalTrials.gov
['NCT03870828']
Types de publication
Clinical Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical University of Silesia
ID : PCN-1-066/K/2/K
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