Cruciate DNA probes for amplified multiplexed imaging of microRNAs in living cells.

MicroRNAs / genetics DNA / genetics Cell Line, Tumor DNA Probes / genetics Optical Imaging

Journal

Journal of materials chemistry. B
ISSN: 2050-7518
Titre abrégé: J Mater Chem B
Pays: England
ID NLM: 101598493

Informations de publication

Date de publication:
22 12 2022
Historique:
pubmed: 13 12 2022
medline: 24 12 2022
entrez: 12 12 2022
Statut: epublish

Résumé

The real-time imaging of low-abundance tumor-related microRNAs (miRNAs) in living cells holds great potential for early clinical diagnosis of cancers. However, the relatively low detection sensitivity and possible false-positive signals of a probe in complex cellular matrices remain critical challenges for accurate RNA detection. Herein, we developed a novel aptamer-functionalized cruciate DNA probe that enabled amplified multiple miRNA imaging in living cells

Identifiants

DOI: 10.1039/d2tb02027k PMID: 36504047
pubmed: 36504047
doi: 10.1039/d2tb02027k
doi:

Substances chimiques

MicroRNAs 0
DNA 9007-49-2
DNA Probes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

204-210

Auteurs

Zhe Dong (Z)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, China.

Xizhu Xu (X)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Jing Ni (J)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Yuancheng Li (Y)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Kang An (K)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Ling Meng (L)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Han Wu (H)

School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
ORCID: 0000-0003-4349-3792

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Cruciate DNA probes for amplified multiplexed...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Cruciate DNA probes for amplified multiplexed...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cruciate DNA probes for amplified multiplexed...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Sondes d'ADN › Cruciate DNA probes for amplified multiplexed...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Cruciate DNA probes for amplified multiplexed...