The genetic regulation of protein expression in cerebrospinal fluid.

Humans Alzheimer Disease / genetics Matrix Metalloproteinase 10 / genetics Parkinson Disease / genetics Proteomics Quantitative Trait Loci Biomarkers / cerebrospinal fluid Antigens, CD Sialic Acid Binding Immunoglobulin-like Lectins / genetics Membrane Proteins / genetics ADAM Proteins / genetics Membrane Glycoproteins / genetics
Mendelian randomization biomarkers cerebrospinal fluid genetic regulation pQTL

Journal

EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380

Informations de publication

Date de publication:
11 01 2023
Historique:
revised: 12 11 2022
received: 23 05 2022
accepted: 14 11 2022
pubmed: 13 12 2022
medline: 13 1 2023
entrez: 12 12 2022
Statut: ppublish

Résumé

Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 participants from the BioFINDER study. Protein quantitative trait loci (pQTL) were identified as associations between genetic variants and proteins, with 176 pQTLs for 145 CSF proteins (P < 1.25 × 10

Identifiants

DOI: 10.15252/emmm.202216359 PMID: 36504281 PMC: PMC9832827
pubmed: 36504281
doi: 10.15252/emmm.202216359
pmc: PMC9832827
doi:

Substances chimiques

Matrix Metalloproteinase 10 EC 3.4.24.22
Biomarkers 0
SIGLEC9 protein, human 0
Antigens, CD 0
Sialic Acid Binding Immunoglobulin-like Lectins 0
ADAM15 protein, human EC 3.4.24.-
Membrane Proteins 0
ADAM Proteins EC 3.4.24.-
GPNMB protein, human 0
Membrane Glycoproteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e16359

Subventions

Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018023
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH066392
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003949
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032990
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025711
Pays : United States
Organisme : European Research Council
ID : 681712
Pays : International
Organisme : NIA NIH HHS
ID : U01 AG046139
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017216
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048015
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080820
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046152
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036836
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States

Informations de copyright

© 2022 The Authors. Published under the terms of the CC BY 4.0 license.

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Auteurs

Oskar Hansson (O)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden.
ORCID: 0000-0001-8467-7286

Atul Kumar (A)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
ORCID: 0000-0002-2166-4805

Shorena Janelidze (S)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.

Erik Stomrud (E)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden.

Philip S Insel (PS)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Kaj Blennow (K)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
ORCID: 0000-0002-1890-4193

Henrik Zetterberg (H)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.

Eric Fauman (E)

Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.

Åsa K Hedman (ÅK)

Pfizer Worldwide Research, Development and Medical, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Michael W Nagle (MW)

Neurogenomics, Genetics-Guided Dementia Discovery, Eisai, Inc, Cambridge, MA, USA.
ORCID: 0000-0002-4677-7582

Christopher D Whelan (CD)

Translational Biology, Biogen Research & Development, Biogen Inc, Cambridge, MA, USA.

Denis Baird (D)

Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.

Anders Mälarstig (A)

Pfizer Worldwide Research, Development and Medical, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Niklas Mattsson-Carlgren (N)

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.
Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
ORCID: 0000-0002-8885-7724

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The genetic regulation of protein expression...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › The genetic regulation of protein expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 10 › The genetic regulation of protein expression...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › The genetic regulation of protein expression...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › The genetic regulation of protein expression...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › The genetic regulation of protein expression...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The genetic regulation of protein expression...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › The genetic regulation of protein expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines liant l'acide sialique apparentées aux immunoglobulines › The genetic regulation of protein expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › The genetic regulation of protein expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéines ADAM › The genetic regulation of protein expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › The genetic regulation of protein expression...