Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion-symptom mapping study in 3525 memory clinic patients.

Humans White Matter / diagnostic imaging Magnetic Resonance Imaging Cognitive Dysfunction / diagnostic imaging Cognition Executive Function Neuropsychological Tests
cognitive impairment lesion symptom mapping location memory clinic patients white matter hyperintensities

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
06 2023
Historique:
revised: 07 09 2022
received: 19 04 2022
accepted: 13 09 2022
medline: 13 6 2023
pubmed: 13 12 2022
entrez: 12 12 2022
Statut: ppublish

Résumé

Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses. WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.

Identifiants

DOI: 10.1002/alz.12827 PMID: 36504357
pubmed: 36504357
doi: 10.1002/alz.12827
doi:

Types de publication

Multicenter Study Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2420-2432

Subventions

Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072972
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00019/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/3
Pays : United Kingdom

Informations de copyright

© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Mirthe Coenen (M)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
ORCID: 0000-0002-7901-8232

Hugo J Kuijf (HJ)

Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.

Irene M C Huenges Wajer (IMC)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

Marco Duering (M)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University of Basel, Basel, Switzerland.

Frank J Wolters (FJ)

Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Evan F Fletcher (EF)

Department of Neurology, University of California at Davis, Davis, California, USA.

Pauline M Maillard (PM)

Department of Neurology, University of California at Davis, Davis, California, USA.
Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.

Frederik Barkhof (F)

Radiology & Nuclear Medicine, Amsterdam UMC, location Vrije Universiteit, Amsterdam, The Netherlands.
UCL Institute of Neurology, London, UK.

Josephine Barnes (J)

Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.

Thomas Benke (T)

Clinic of Neurology, Medical University Innsbruck, Innsbruck, Austria.

Jooske M F Boomsma (JMF)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Christopher P L H Chen (CPLH)

Department of Pharmacology, National University of Singapore, Singapore, Singapore.
Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.

Peter Dal-Bianco (P)

Department of Neurology, Medical University Vienna, Vienna, Austria.

Anna Dewenter (A)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Christian Enzinger (C)

Division of General Neurology, Department of Neurology, Medical University Graz, Graz, Austria.
Division of Neuroradiology, Interventional and Vascular Radiology, Department of Radiology, Medical University of Graz, Graz, Austria.

Michael Ewers (M)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Lieza G Exalto (LG)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.

Nicolai Franzmeier (N)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Onno Groeneveld (O)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
Department of Neurology, Isala MS Centre, Isala Hospital, Meppel, The Netherlands.

Saima Hilal (S)

Department of Pharmacology, National University of Singapore, Singapore, Singapore.
Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Edith Hofer (E)

Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Dineke L Koek (DL)

Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Andrea B Maier (AB)

Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Department of Medicine, National University of Singapore, Singapore, Singapore.

Cheryl R McCreary (CR)

Department of Clinical Neurosciences and Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Catarina S Padilla (CS)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.

Janne M Papma (JM)

Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Ross W Paterson (RW)

Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.

Yolande A L Pijnenburg (YAL)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Anna Rubinski (A)

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Reinhold Schmidt (R)

Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.

Jonathan M Schott (JM)

Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.

Catherine F Slattery (CF)

Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, UK.

Eric E Smith (EE)

Department of Clinical Neurosciences and Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Rebecca M E Steketee (RME)

Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Carole H Sudre (CH)

MRC Unit for Lifelong Health and Ageing, the Centre for Medical Image Computing, UCL, London, UK.

Esther van den Berg (E)

Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Wiesje M van der Flier (WM)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Narayanaswamy Venketasubramanian (N)

Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.
Raffles Neuroscience Center, Raffles Hospital, Singapore, Singapore.

Meike W Vernooij (MW)

Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Xu Xin (X)

Department of Pharmacology, National University of Singapore, Singapore, Singapore.
Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore.

Charles DeCarli (C)

Department of Neurology, University of California at Davis, Davis, California, USA.

Geert Jan Biessels (GJ)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.

J Matthijs Biesbroek (JM)

Department of Neurology and Neurosurgery, UMC Utrecht, Brain Center, Utrecht, The Netherlands.
Department of Neurology, Diakonessenhuis Hospital, Utrecht, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Strategic white matter hyperintensity...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Strategic white matter hyperintensity...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Strategic white matter hyperintensity...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Strategic white matter hyperintensity...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Strategic white matter hyperintensity...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Fonction exécutive › Strategic white matter hyperintensity...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Strategic white matter hyperintensity...