Glucocorticoid receptor hypersensitivity enhances inflammatory signaling and inhibits cell cycle progression in porcine PBMCs.
cell cycle progression
glucocorticoid receptor hypersensitivity
inflammatory signaling
lipopolysaccharide
pattern recognition receptors
porcine PBMCs
transcriptome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
06
2022
accepted:
10
11
2022
entrez:
12
12
2022
pubmed:
13
12
2022
medline:
15
12
2022
Statut:
epublish
Résumé
The consequences of glucocorticoid receptor (GR) hypersensitivity during infection have so far received little attention. We previously discovered that a natural gain-of-function Ala610Val substitution in the porcine GR aggravates response of pigs to lipopolysaccharide (LPS)-induced endotoxemia, which can be alleviated by dexamethasone (DEX) pretreatment. In this work, we investigated the relevant molecular basis of these phenotypes by transcriptomic profiling of porcine peripheral blood mononuclear cells (PBMCs) carrying different GR genotypes, in unstimulated conditions or in response to DEX and/or LPS
Identifiants
pubmed: 36505401
doi: 10.3389/fimmu.2022.976454
pmc: PMC9730246
doi:
Substances chimiques
Receptors, Glucocorticoid
0
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
976454Informations de copyright
Copyright © 2022 Li, Hadlich, Wimmers and Murani.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Cell Biol. 2000 Dec;20(23):9009-17
pubmed: 11073999
J Biol Chem. 2007 Apr 6;282(14):10660-9
pubmed: 17303569
Cell Cycle. 2017;16(21):2058-2072
pubmed: 28880708
Nat Immunol. 2011 May;12(5):416-24
pubmed: 21441935
PLoS One. 2016 Oct 13;11(10):e0164628
pubmed: 27736993
Cell Death Dis. 2016 Jan 14;7:e2051
pubmed: 26775703
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612
pubmed: 33237311
Genes Dev. 2005 Jan 15;19(2):196-201
pubmed: 15655109
Mol Biol Cell. 2007 Nov;18(11):4659-68
pubmed: 17855507
J Immunol. 2007 Feb 15;178(4):2380-6
pubmed: 17277144
Front Immunol. 2019 Mar 06;10:360
pubmed: 30894857
Endocr Rev. 2000 Feb;21(1):55-89
pubmed: 10696570
Front Immunol. 2020 Jul 21;11:1318
pubmed: 32849493
Cell Death Differ. 2019 Oct;26(10):2046-2060
pubmed: 30742091
Brief Funct Genomics. 2013 Nov;12(6):489-98
pubmed: 23943603
Science. 2005 Mar 11;307(5715):1630-4
pubmed: 15761154
Mediators Inflamm. 2014;2014:821043
pubmed: 25140116
BMC Syst Biol. 2014;8 Suppl 4:S11
pubmed: 25521941
Cytokine Growth Factor Rev. 2017 Jun;35:85-96
pubmed: 28479044
Biochim Biophys Acta. 2011 May;1813(5):878-88
pubmed: 21296109
J Immunol. 2007 Oct 15;179(8):5514-22
pubmed: 17911638
Front Immunol. 2019 Jul 04;10:1545
pubmed: 31333672
Cell Discov. 2020 Feb 11;6:6
pubmed: 32047650
J Biol Chem. 2010 Oct 1;285(40):31073-86
pubmed: 20663891
Contrib Nephrol. 2010;167:14-24
pubmed: 20519895
Open Biol. 2016 Jul;6(7):
pubmed: 27440422
Cells. 2021 Oct 28;10(11):
pubmed: 34831143
Genome Biol. 2014;15(12):550
pubmed: 25516281
Exp Cell Res. 2022 Mar 15;412(2):113035
pubmed: 35065924
FASEB J. 2012 Feb;26(2):722-9
pubmed: 22042221
Science. 2015 Mar 13;347(6227):aaa2630
pubmed: 25636800
Oncogene. 2006 Aug 28;25(38):5220-7
pubmed: 16936740
Endocr Rev. 2014 Aug;35(4):671-93
pubmed: 24937701
Contrib Nephrol. 2010;167:1-13
pubmed: 20519894
Compr Physiol. 2014 Jul;4(3):1273-98
pubmed: 24944037
Mol Plant. 2020 Aug 3;13(8):1194-1202
pubmed: 32585190
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
Thromb Haemost. 2015 Aug 31;114(3):478-89
pubmed: 25904241
Nat Immunol. 2005 Jun;6(6):571-8
pubmed: 15852007
Nat Immunol. 2001 Apr;2(4):338-45
pubmed: 11276205
Cell Physiol Biochem. 2018;47(6):2278-2290
pubmed: 29975947
Mol Psychiatry. 2013 Sep;18(9):1006-17
pubmed: 23089634
Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(6):261-277
pubmed: 31189779
Immune Netw. 2018 Aug 13;18(4):e27
pubmed: 30181915
J Immunol. 2018 May 1;200(9):3218-3230
pubmed: 29563175
Brain Behav Immun. 2020 Nov;90:174-183
pubmed: 32795657
Int J Mol Sci. 2021 Jun 10;22(12):
pubmed: 34200950
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Vet Immunol Immunopathol. 2015 Aug 15;166(3-4):58-69
pubmed: 26099806
Front Oncol. 2017 Mar 31;7:51
pubmed: 28409123
Nat Immunol. 2009 Oct;10(10):1089-95
pubmed: 19734906
Front Immunol. 2019 Aug 06;10:1748
pubmed: 31447831
PLoS One. 2012;7(9):e45518
pubmed: 23029068
Nat Rev Immunol. 2015 Apr;15(4):203-16
pubmed: 25720354
Biochim Biophys Acta. 2012 Jan;1824(1):14-21
pubmed: 21782984
Virulence. 2021 Dec;12(1):1808-1824
pubmed: 34288827
Blood. 2003 Aug 15;102(4):1374-80
pubmed: 12714520
Mol Endocrinol. 2015 Apr;29(4):502-17
pubmed: 25647480
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20054-9
pubmed: 22123964
Tissue Eng. 2000 Jun;6(3):241-51
pubmed: 10941219
Signal Transduct Target Ther. 2021 Aug 4;6(1):291
pubmed: 34344870
Front Immunol. 2019 Aug 09;10:1769
pubmed: 31447832
Cell Host Microbe. 2017 Jun 14;21(6):719-730.e6
pubmed: 28579255
Intensive Care Med Exp. 2019 Dec 2;7(1):64
pubmed: 31792745
Mol Cell Oncol. 2015 Jan 30;2(1):e970480
pubmed: 27308406
Nat Commun. 2019 Apr 3;10(1):1523
pubmed: 30944313
Database (Oxford). 2016 Jul 03;2016:
pubmed: 27374120
Int J Mol Sci. 2020 Jan 07;21(2):
pubmed: 31936182
Cancer Lett. 2016 Oct 10;381(1):165-75
pubmed: 27477901
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Front Immunol. 2019 Jul 17;10:1687
pubmed: 31379873
Front Cell Dev Biol. 2020 Nov 16;8:599281
pubmed: 33304904
Front Cell Dev Biol. 2017 Dec 07;5:106
pubmed: 29270406
Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii
pubmed: 26611548
J Immunol. 2007 May 15;178(10):6307-15
pubmed: 17475859