Transformation of Hydrophilic Drug into Oil-Miscible Ionic Liquids for Transdermal Drug Delivery.

Mice Animals Administration, Cutaneous Ionic Liquids / chemistry Skin Absorption Stearates Laurates Linoleic Acid Oleic Acid / pharmacology Skin Drug Carriers / chemistry Solvents Permeability Drug Delivery Systems / methods
biocompatible ionic liquid pharmacokinetics skin permeation transdermal delivery

Journal

ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991

Informations de publication

Date de publication:
21 Dec 2022
Historique:
pubmed: 13 12 2022
medline: 24 12 2022
entrez: 12 12 2022
Statut: ppublish

Résumé

The transdermal delivery of hydrophilic drugs remains challenging owing to their poor ability to permeate the skin; formulation with oil media is difficult without adding chemical permeation enhancers or co-solvents. Herein, we synthesized 12 oil-miscible ionic liquid (IL) drugs comprising lidocaine-, imipramine-, and levamisole (Lev)-hydrochloride with fatty acid permeation enhancers, i.e., laurate, oleate, linoleate, and stearate as counterions. A set of

Identifiants

DOI: 10.1021/acsami.2c15636 PMID: 36508194
pubmed: 36508194
doi: 10.1021/acsami.2c15636
doi:

Substances chimiques

Ionic Liquids 0
Stearates 0
Laurates 0
Linoleic Acid 9KJL21T0QJ
Oleic Acid 2UMI9U37CP
Drug Carriers 0
Solvents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

55332-55341

Auteurs

Rahman Md Moshikur (R)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0002-0932-3741

Islam Md Shimul (IM)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh.

Shihab Uddin (S)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Rie Wakabayashi (R)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Muhammad Moniruzzaman (M)

Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia.
ORCID: 0000-0002-2523-4159

Masahiro Goto (M)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0002-2008-9351

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Eucaryotes › Animaux › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Liquides ioniques › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Absorption cutanée › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Lipides › Acides gras › Acides stéariques › Stéarate › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Lipides › Acides gras › Acides lauriques › Laurate › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acides linoléiques › Acide linoléique › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Acide oléique › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Système tégumentaire › Peau › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Transformation of Hydrophilic Drug into...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Transformation of Hydrophilic Drug into...