Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)-A Randomized Controlled Trial.
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
received:
18
08
2022
accepted:
15
11
2022
pubmed:
13
12
2022
medline:
31
1
2023
entrez:
12
12
2022
Statut:
ppublish
Résumé
To investigate the safety and feasibility of 3 nonconsecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated type 2 diabetes. Forty-six people were randomized to an IF or control group. Dietary counseling and continuous glucose monitoring was provided. Coprimary end points were the change in HbA1c from baseline to 12 weeks and a composite end point (weight reduction ≥2%, insulin dose reduction ≥10%, and HbA1c reduction ≥3 mmol/mol). The IF group showed a significant HbA1c reduction (-7.3 ± 12.0 mmol/mol) compared with the control group (0.1 ± 6.1 mmol/mol) over 12 weeks (P = 0.012). The coprimary end point was achieved by 8 people in the IF and none in the control group (P < 0.001). No severe hypoglycemia occurred. IF is a safe and feasible dietary option to ameliorate glycemic control while reducing total daily insulin dose and body weight in insulin-treated people with type 2 diabetes.
Identifiants
pubmed: 36508320
pii: 148123
doi: 10.2337/dc22-1622
pmc: PMC9887629
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin
0
Hypoglycemic Agents
0
Insulin
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-468Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 851
Pays : Austria
Informations de copyright
© 2023 by the American Diabetes Association.
Références
Diabetes Care. 2018 Dec;41(12):2669-2701
pubmed: 30291106
Diabetes Care. 2014 Aug;37(8):2108-13
pubmed: 24824546
Transl Res. 2014 Oct;164(4):302-11
pubmed: 24993615
JAMA Netw Open. 2018 Jul 6;1(3):e180756
pubmed: 30646030
Nutr Healthy Aging. 2018 Jun 15;4(4):345-353
pubmed: 29951594
J Clin Endocrinol Metab. 2021 Mar 8;106(3):902-911
pubmed: 33319233
Diabetes Res Clin Pract. 2021 Feb;172:108589
pubmed: 33316309
Obesity (Silver Spring). 2018 Feb;26(2):254-268
pubmed: 29086496
Exp Clin Endocrinol Diabetes. 2017 Oct;125(9):618-624
pubmed: 28407662
Prog Cardiovasc Dis. 2017 Nov - Dec;60(3):422-434
pubmed: 28958751
Nutrients. 2021 Sep 03;13(9):
pubmed: 34578983
Cell Metab. 2020 Sep 1;32(3):366-378.e3
pubmed: 32673591
Lancet. 2016 Apr 9;387(10027):1513-1530
pubmed: 27061677
Diabetes Res Clin Pract. 2021 Sep;179:109003
pubmed: 34391831
Diabet Med. 2022 Jun;39(6):e14813
pubmed: 35179802
Diabetes Care. 2019 May;42(5):731-754
pubmed: 31000505
Nat Rev Endocrinol. 2022 May;18(5):309-321
pubmed: 35194176