TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study.
Aged
Female
Humans
Male
Alzheimer Disease
/ metabolism
Amyloid beta-Peptides
/ metabolism
Apolipoprotein E4
Biomarkers
Cross-Sectional Studies
Growth Differentiation Factor 15
Independent Living
Inflammation
Interleukin-6
Intermediate Filaments
/ metabolism
Progranulins
/ blood
Receptors, Tumor Necrosis Factor, Type I
Neurofilament Proteins
/ blood
Neurodegenerative Diseases
/ diagnosis
Amyloid-β
Cognitive decline
Inflammation
Neurodegeneration
Nutrition
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
30 03 2023
30 03 2023
Historique:
received:
21
07
2022
medline:
31
3
2023
pubmed:
13
12
2022
entrez:
12
12
2022
Statut:
ppublish
Résumé
There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β 42/40-Aβ 42/40, neurofilament light chain-NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine-Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1-TNFR-1, monocyte chemoattractant protein 1-MCP-1, interleukin 6-IL-6), and cellular stress (plasma growth differentiation factor 15-GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ 42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration. Clinical Trials Registration Number: NCT00672685.
Identifiants
pubmed: 36508390
pii: 6889460
doi: 10.1093/gerona/glac244
pmc: PMC10061943
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoprotein E4
0
Biomarkers
0
Growth Differentiation Factor 15
0
Interleukin-6
0
Progranulins
0
Receptors, Tumor Necrosis Factor, Type I
0
neurofilament protein L
0
Neurofilament Proteins
0
Banques de données
ClinicalTrials.gov
['NCT00672685']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
569-578Subventions
Organisme : NIA NIH HHS
ID : RF1 AG061900
Pays : United States
Organisme : NIA NIH HHS
ID : R56AG061900
Pays : United States
Investigateurs
Bruno Vellas
(B)
Sophie Guyonnet
(S)
Isabelle Carrié
(I)
Lauréane Brigitte
(L)
Catherine Faisant
(C)
Françoise Lala
(F)
Julien Delrieu
(J)
Hélène Villars
(H)
Emeline Combrouze
(E)
Carole Badufle
(C)
Audrey Zueras
(A)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Christophe Morin
(C)
Gabor Abellan Van Kan
(G)
Charlotte Dupuy
(C)
Yves Rolland
(Y)
Céline Caillaud
(C)
Pierre-Jean Ousset
(PJ)
Fabrice Bonneville
(F)
Christophe Cognard
(C)
François Chollet
(F)
Pierre Payoux
(P)
Thierry Voisin
(T)
Julien Delrieu
(J)
Sophie Peiffer
(S)
Anne Hitzel
(A)
Laurent Molinier
(L)
Hélène Derumeaux
(H)
Nadège Costa
(N)
Bertrand Perret
(B)
Claire Vinel
(C)
Sylvie Caspar-Bauguil
(S)
Pascale Olivier-Abbal
(P)
Sandrine Andrieu
(S)
Christelle Cantet
(C)
Nicola Coley
(N)
Sherry Willis
(S)
Sylvie Belleville
(S)
Brigitte Gilbert
(B)
Francine Fontaine
(F)
Jean-François Dartigues
(JF)
Isabelle Marcet
(I)
Fleur Delva
(F)
Alexandra Foubert
(A)
Sandrine Cerda
(S)
Carole Dufouil
(C)
Michèle Allard
(M)
Michèle Allard
(M)
Marie Noëlle-Cuffi
(M)
Corinne Costes
(C)
Olivier Rouaud
(O)
Patrick Manckoundia
(P)
Valérie Quipourt
(V)
Sophie Marilier
(S)
Evelyne Franon
(E)
Frédéric Ricolfi
(F)
Lawrence Bories
(L)
Marie-Laure Pader
(ML)
Marie-France Basset
(MF)
Bruno Lapoujade
(B)
Valérie Faure
(V)
Michael Li Yung Tong
(M)
Christine Malick-Loiseau
(C)
Evelyne Cazaban-Campistron
(E)
Dominique Dubois
(D)
Françoise Desclaux
(F)
Colette Blatge
(C)
Thierry Dantoine
(T)
Cécile Laubarie-Mouret
(C)
Isabelle Saulnier
(I)
Jean-Pierre Clément
(JP)
Marie-Agnès Picat
(MA)
Laurence Bernard-Bourzeix
(L)
Stéphanie Willebois
(S)
Iléana Désormais
(I)
Noëlle Cardinaud
(N)
Marie Paule Bonceour Martel
(M)
Jacques Monteil
(J)
Marc Bonnefoy
(M)
Pierre Livet
(P)
Pascale Rebaudet
(P)
Claire Gédéon
(C)
Catherine Burdet
(C)
Flavien Terracol
(F)
François Cotton
(F)
Alain Pesce
(A)
Stéphanie Roth
(S)
Sylvie Chaillou
(S)
Sandrine Louchart
(S)
Kristel Sudres
(K)
Nicolas Lebrun
(N)
Nadège Barro-Belaygues
(N)
Jacques Touchon
(J)
Karim Bennys
(K)
Audrey Gabelle
(A)
Aurélia Romano
(A)
Lynda Touati
(L)
Cécilia Marelli
(C)
Cécile Pays
(C)
Alain Bonafé
(A)
Michel Zanca
(M)
Philippe Robert
(P)
Franck Le Duff
(F)
Claire Gervais
(C)
Sébastien Gonfrier
(S)
Stéphane Chanalet
(S)
Jacques Darcourt
(J)
Yannick Gasnier
(Y)
Serge Bordes
(S)
Danièle Begorre
(D)
Christian Carpuat
(C)
Khaled Khales
(K)
Jean-François Lefebvre
(JF)
Samira Misbah El Idrissi
(S)
Pierre Skolil
(P)
Jean-Pierre Salles
(JP)
Françoise Hugon
(F)
Stéphane Lehéricy
(S)
Marie Chupin
(M)
Jean-François Mangin
(JF)
Ali Bouhayia
(A)
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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