Aging-associated HELIOS deficiency in naive CD4


Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
01 2023
Historique:
received: 15 01 2022
accepted: 24 10 2022
pmc-release: 01 01 2024
pubmed: 13 12 2022
medline: 6 1 2023
entrez: 12 12 2022
Statut: ppublish

Résumé

Immune aging combines cellular defects in adaptive immunity with the activation of pathways causing a low-inflammatory state. Here we examined the influence of age on the kinetic changes in the epigenomic and transcriptional landscape induced by T cell receptor (TCR) stimulation in naive CD4

Identifiants

pubmed: 36510022
doi: 10.1038/s41590-022-01369-x
pii: 10.1038/s41590-022-01369-x
pmc: PMC10118794
mid: NIHMS1879118
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
STAT5 Transcription Factor 0
IKZF2 protein, human 0
Ikaros Transcription Factor 148971-36-2

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

96-109

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI129191
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142068
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108906
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108891
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR042527
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117913
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Huimin Zhang (H)

Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.

Rohit R Jadhav (RR)

Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.

Wenqiang Cao (W)

Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.
Health Sciences Institute, China Medical University, Shenyang, China.

Isabel N Goronzy (IN)

Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA, USA.

Tuantuan V Zhao (TV)

Department of Medicine, Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Jun Jin (J)

Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.

Shozo Ohtsuki (S)

Department of Medicine, Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Zhaolan Hu (Z)

Department of Medicine, Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Jose Morales (J)

Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

William J Greenleaf (WJ)

Department of Genetics, Stanford University, Palo Alto, Stanford, CA, USA.

Cornelia M Weyand (CM)

Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.
Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Jörg J Goronzy (JJ)

Department of Immunology, Mayo Clinic, Rochester, MN, USA. goronzy.jorg@mayo.edu.
Department of Medicine, Stanford University, Stanford, CA, USA. goronzy.jorg@mayo.edu.
Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA. goronzy.jorg@mayo.edu.

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