Poly(pro-curcumin) Materials Exhibit Dual Release Rates and Prolonged Antioxidant Activity as Thin Films and Self-Assembled Particles.

Curcumin / pharmacology Antioxidants / pharmacology Drug Carriers Polymers Polyethylene Glycols Polyesters

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
09 01 2023
Historique:
pubmed: 14 12 2022
medline: 11 1 2023
entrez: 13 12 2022
Statut: ppublish

Résumé

Curcumin is a natural polyphenol that exhibits remarkable antioxidant and anti-inflammatory activities; however, its clinical application is limited in part by its physiological instability. Here, we report the synthesis of curcumin-derived polyesters that release curcumin upon hydrolytic degradation to improve curcumin stability and solubility in physiological conditions. Curcumin was incorporated in the polymer backbone by a one-pot condensation polymerization in the presence of sebacoyl chloride and polyethylene glycol (PEG,

Identifiants

DOI: 10.1021/acs.biomac.2c01135 PMID: 36512693
pubmed: 36512693
doi: 10.1021/acs.biomac.2c01135
doi:

Substances chimiques

Curcumin IT942ZTH98
Antioxidants 0
Drug Carriers 0
Polymers 0
Polyethylene Glycols 3WJQ0SDW1A
Polyesters 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

294-307

Auteurs

Ruiwen Chen (R)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.

Jessica L Funnell (JL)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.

Geraldine B Quinones (GB)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.

Marvin Bentley (M)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.

Jeffrey R Capadona (JR)

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Advanced Platform Technology Center, L. Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, United States.

Ryan J Gilbert (RJ)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Albany Stratton Veteran Affairs Medical Center, Albany, New York 12208, United States.
ORCID: 0000-0002-3501-6753

Edmund F Palermo (EF)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Department of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
ORCID: 0000-0003-3656-787X

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Poly(pro-curcumin) Materials Exhibit Dual...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Poly(pro-curcumin) Materials Exhibit Dual...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Poly(pro-curcumin) Materials Exhibit Dual...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Poly(pro-curcumin) Materials Exhibit Dual...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Poly(pro-curcumin) Materials Exhibit Dual...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Poly(pro-curcumin) Materials Exhibit Dual...