Long-Term Outcomes of Biological Therapy in Crohn's Disease Complicated With Internal Fistulizing Disease: BIOSCOPE Study From GETECCU.


Journal

The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030

Informations de publication

Date de publication:
01 06 2023
Historique:
received: 11 07 2022
accepted: 14 11 2022
medline: 2 6 2023
pubmed: 15 12 2022
entrez: 14 12 2022
Statut: ppublish

Résumé

The prevalence of penetrating complications in Crohn's disease (CD) increases progressively over time, but evidence on the medical treatment in this setting is limited. The aim of this study was to evaluate the effectiveness of biologic agents in CD complicated with internal fistulizing disease. Adult patients with CD-related fistulae who received at least 1 biologic agent for this condition from the prospectively maintained ENEIDA registry were included. Exclusion criteria involved those receiving biologics for perianal disease, enterocutaneous, rectovaginal, anastomotic, or peristomal fistulae. The primary end point was fistula-related surgery. Predictive factors associated with surgery and fistula closure were evaluated by multivariate logistic regression and survival analyses. A total of 760 patients from 53 hospitals (673 receiving anti-tumor necrosis factors, 69 ustekinumab, and 18 vedolizumab) were included. After a median follow-up of 56 months (interquartile range, 26-102 months), 240 patients required surgery, with surgery rates of 32%, 41%, and 24% among those under anti-tumor necrosis factor, vedolizumab, or ustekinumab, respectively. Fistula closure was observed in 24% of patients. Older patients, ileocolonic disease, entero-urinary fistulae, or an intestinal stricture distal to the origin of the fistula were associated with a higher risk of surgery, whereas nonsmokers and combination therapy with an immunomodulator reduced this risk. Biologic therapy is beneficial in approximately three-quarters of patients with fistulizing CD, achieving fistula closure in 24%. However, around one-third still undergo surgery due to refractory disease. Some patient- and lesion-related factors can identify patients who will obtain more benefit from these drugs.

Identifiants

pubmed: 36516073
doi: 10.14309/ajg.0000000000002152
pii: 00000434-202306000-00024
doi:

Substances chimiques

Ustekinumab FU77B4U5Z0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1036-1046

Informations de copyright

Copyright © 2023 by The American College of Gastroenterology.

Références

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Auteurs

Manuel Barreiro-de Acosta (M)

Department of Gastroenterology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Agnès Fernández-Clotet (A)

Department of Gastroenterology, Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

Francisco Mesonero (F)

Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Francisco Javier García-Alonso (FJ)

Department of Gastroenterology, Hospital Universitario Río Hortega, Valladolid, Spain.

María José Casanova (MJ)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Margarita Fernández-de la Varga (M)

Department of Gastroenterology, Hospital Universitari i Politecnic la Fe, Valencia, Spain.

Fiorella Cañete (F)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitari German Trias i Pujol, Badalona, Spain.

Luisa de Castro (L)

Department of Gastroenterology, Hospital Álvaro Cunqueiro, Vigo, Spain.

Ana Gutiérrez (A)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain.

Beatriz Sicilia (B)

Department of Gastroenterology, Hospital Universitario de Burgos, Burgos, Spain.

Victoria Cano (V)

Department of Gastroenterology, Hospital Universitario de León, León, Spain.

Olga Merino (O)

Department of Gastroenterology, Hospital Universitario de Cruces, Barakaldo, Spain.

Ruth de Francisco (R)

Department of Gastroenterology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Irene González-Partida (I)

Department of Gastroenterology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

Gerard Surís (G)

Department of Gastroenterology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

Leyanira Torrealba (L)

Department of Gastroenterology, Hospital Universitari Dr. Josep Trueta, Girona, Spain.

Rocío Ferreiro-Iglesias (R)

Department of Gastroenterology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Beatriz Castro (B)

Department of Gastroenterology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Lucía Márquez (L)

Department of Gastroenterology, Hospital del Mar, Barcelona, Spain.

Ana Sobrino (A)

Department of Gastroenterology, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.

Ainara Elorza (A)

Department of Gastroenterology, Hospital Universitario de Galdakao, Biocruces Bizkaia Health Research Institute, Galdakao, Spain.

Xavier Calvet (X)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Corporació Sanitària Universitària Parc Taulí, Sabadell, Spain.

Pilar Varela (P)

Department of Gastroenterology, Hospital de Cabueñes, Gijón, Spain.

Raquel Vicente (R)

Department of Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Luis Bujanda (L)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitario Donostia and Instituto Biodonostia, Universidad del País Vasco (UPV/EHU), Donostia, Spain.

Laura Lario (L)

Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.

Noemí Manceñido (N)

Department of Gastroenterology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Spain.

Mariana F García-Sepulcre (MF)

Department of Gastroenterology, Hospital General Universitario de Elche, Elche, Spain.

Eva Iglesias (E)

Department of Gastroenterology, Hospital Universitario Reina Sofía, IMIBIC, Córdoba, Spain.

Cristina Rodríguez (C)

Department of Gastroenterology, Hospital Universitario de Navarra, Pamplona, Spain.

Marta Piqueras (M)

Department of Gastroenterology, Consorci Sanitari de Terrassa, Terrassa, Spain.

Juan Ángel Ferrer Rosique (JÁ)

Department of Gastroenterology, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain.

Alfredo J Lucendo (AJ)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital General de Tomelloso and Instituto de Investigación Sanitaria Princesa, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Tomelloso, Spain.

Olga Benítez (O)

Department of Gastroenterology, Hospital Universitari Mútua Terrassa, Terrassa, Spain.

Melody García (M)

Department of Gastroenterology, Hospital General San Jorge, Huesca, Spain.

David Olivares (D)

Department of Gastroenterology, Hospital Clínico San Carlos, Madrid, Spain.

Carlos González-Muñoza (C)

Department of Gastroenterology, Hospital Santa Creu i Sant Pau, Barcelona, Spain.

Beatriz López-Cauce (B)

Department of Gastroenterology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Victor Jair Morales Alvarado (VJ)

Department of Gastroenterology, Hospital General de Granollers, Granollers, Spain.

Katerina Spicakova (K)

Department of Gastroenterology, Hospital Universitario Araba, Vitoria, Spain.

Alicia Brotons (A)

Department of Gastroenterology, Hospital Vega Baja, Alicante, Spain.

Fernando Bermejo (F)

Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Instituto de Investigación Sanitaria La Paz (IdiPAZ), Fuenlabrada, Spain.

Pedro Almela (P)

Department of Gastroenterology, Hospital General de Castellón, Castellón, Spain.

Nahia Ispízua (N)

Department of Gastroenterology, Hospital Universitario de Basurto, Bilbao, Spain.

Pau Gilabert (P)

Department of Gastroenterology, Hospital de Viladecans, Viladecans, Spain.

Carlos Tardillo (C)

Department of Gastroenterology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.

Fernando Muñoz (F)

Department of Gastroenterology, Hospital Universitario de Salamanca, Salamanca, Spain.

Pablo Navarro (P)

Department of Gastroenterology, Hospital Clínico Universitario de Valencia, Valencia, Spain.

Rosa Eva Madrigal Domínguez (RE)

Department of Gastroenterology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Pau Sendra (P)

Department of Gastroenterology, Hospital Son Espases, Palma, Spain.

Esther Hinojosa (E)

Department of Gastroenterology, Hospital de Manises, Manises, Spain.

Empar Sáinz (E)

Department of Gastroenterology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain.

María Dolores Martín-Arranz (MD)

Department of Gastroenterology, Hospital Universitario de la Paz, Madrid, Spain.

Daniel Carpio (D)

Department of Gastroenterology, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain.

Elena Ricart (E)

Department of Gastroenterology, Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

Berta Caballol (B)

Department of Gastroenterology, Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

Laura Núñez (L)

Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Jesús Barrio (J)

Department of Gastroenterology, Hospital Universitario Río Hortega, Valladolid, Spain.

Javier P Gisbert (JP)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Marisa Iborra (M)

Department of Gastroenterology, Hospital Universitari i Politecnic la Fe, Valencia, Spain.

Margalida Calafat (M)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitari German Trias i Pujol, Badalona, Spain.

Vicent Hernández (V)

Department of Gastroenterology, Hospital Álvaro Cunqueiro, Vigo, Spain.

Roser Muñoz Pérez (R)

Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain.

José Luis Cabriada (JL)

Department of Gastroenterology, Hospital Universitario de Galdakao, Biocruces Bizkaia Health Research Institute, Galdakao, Spain.

Eugeni Domènech (E)

Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Department of Gastroenterology, Hospital Universitari German Trias i Pujol, Badalona, Spain.

Iago Rodríguez-Lago (I)

Department of Gastroenterology, Hospital Universitario de Galdakao, Biocruces Bizkaia Health Research Institute, Galdakao, Spain.

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