Immune-Mediated Rippling Muscle Disease Associated With Thymoma and Anti-MURC/Cavin-4 Autoantibodies.

Humans Thymoma / complications Autoantibodies Proteomics Myasthenia Gravis / complications Thymus Neoplasms / complications

Journal

Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388

Informations de publication

Date de publication:
01 2023
Historique:
received: 28 07 2022
accepted: 10 10 2022
entrez: 15 12 2022
pubmed: 16 12 2022
medline: 20 12 2022
Statut: epublish

Résumé

Rippling muscle disease (RMD) is characterized by muscle stiffness, muscle hypertrophy, and rippling muscle induced by stretching or percussion. Hereditary RMD is due to sequence variants in the We suspected a paraneoplastic origin and investigated the presence of specific autoantibodies targeting muscle antigens through a combination of Western blotting and affinity purification coupled with mass spectrometry-based proteomic approaches. We identified circulating MURC/Cavin-4 autoantibodies and found strong similarities between histologic features of the patient's muscle and those commonly reported in caveolinopathies. Strikingly, MURC/Cavin-4 autoantibody titer strongly decreased after tumor resection and immunotherapy correlating with complete disappearance of the rippling phenotype and full patient remission. MURC/Cavin-4 autoantibodies may play a pathogenic role in paraneoplastic iRMD associated with thymoma.

Identifiants

DOI: 10.1212/NXI.0000000000200068 PMID: 36522170 PMC: PMC9756388
pubmed: 36522170
pii: 10/1/e200068
doi: 10.1212/NXI.0000000000200068
pmc: PMC9756388
pii:
doi:

Substances chimiques

Autoantibodies 0

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Juliette Svahn (J)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Laurent Coudert (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Nathalie Streichenberger (N)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Alexandra Kraut (A)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Alice Gravier-Dumonceau-Mazelier (A)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Ludivine Rotard (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Laurence Calemard-Michel (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Rita Menassa (R)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Elisabeth Errazuriz-Cerda (E)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Lara Chalabreysse (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Alexis Osseni (A)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Christophe Vial (C)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Laurentiu Jomir (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

François Tronc (F)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Do Le Duy (D)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Emilien Bernard (E)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Vincent Gache (V)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Yohann Couté (Y)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Vincent Jacquemond (V)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Laurent Schaeffer (L)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France.

Pascal Leblanc (P)

From the Electroneuromyography and Neuromuscular Department (J.S., A.G.-D.-M., C.V., L.J., E.B.), Pierre Wertheimer Hospital, Hospices Civils de Lyon; Institut NeuroMyoGène Physiopathologie et Génétique du neurone et du muscle (INMG-PGNM) (J.S., Laurent Coudert, N.S., L.R., L.C.-M., R.M., A.O., E.B., V.G., V.J., L.S., P.L.), CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon, Cedex; Department of Neuropathology (N.S., Lara Chalabreysse), Hospices Civils de Lyon; Univ. Grenoble Alpes (A.K., Y.C.), INSERM, CEA, UMR BioSanté U1292, CNRS, CEA; Department of Molecular Endocrinology and Rare Diseases (L.C.-M., R.M.), Hospices Civils de Lyon; Centre d'imagerie quantitative Lyon Est (CIQLE) (E.E.-C.), Department of Thoracic Surgery (F.T.), Hospices Civils de Lyon; Institut NeuroMyoGène INMG-MeLiS (D.L.D.), CNRS UMR5284, INSERM U1314, SynatAc Team, Faculté de Médecine Rockefeller, Universités de Lyon, Université Claude Bernard Lyon 1; and French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (D.L.D.), Hospices Civils de Lyon, France. pascal.leblanc@univ-lyon1.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immune-Mediated Rippling Muscle Disease...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Maladies lymphatiques › Tumeurs du thymus › Thymome › Immune-Mediated Rippling Muscle Disease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Immune-Mediated Rippling Muscle Disease...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Immune-Mediated Rippling Muscle Disease...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Myasthénie › Immune-Mediated Rippling Muscle Disease...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Maladies lymphatiques › Tumeurs du thymus › Immune-Mediated Rippling Muscle Disease...