Functional Neuroplasticity and Motor Skill Change Following Gross Motor Interventions for Children With Diplegic Cerebral Palsy.
cerebral palsy
functional magnetic resonance imaging
lower extremity
motor skills
neuroplasticity
Journal
Neurorehabilitation and neural repair
ISSN: 1552-6844
Titre abrégé: Neurorehabil Neural Repair
Pays: United States
ID NLM: 100892086
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
pubmed:
17
12
2022
medline:
3
2
2023
entrez:
16
12
2022
Statut:
ppublish
Résumé
Gross motor intervention designs for children with diplegic cerebral palsy (DCP) require an improved understanding of the children's potential for neuroplasticity. To identify relations between functional neuroplasticity and motor skill changes following gross motor interventions for children with DCP. There were 17 participants with DCP (ages 8-16 years; 6 females; Gross Motor Function Classification System Level I [n = 9] and II [n = 8]). Each completed a 6-week gross motor intervention program that was directed toward achievement of individualized motor/physical activity goals. Outcomes were assessed pre/post and 4 to 6 months post-intervention (follow-up). An active ankle dorsiflexion task was completed during functional magnetic resonance imaging. The ratio of motor cortical activation volume in each hemisphere was calculated using a laterality index. The Challenge scores improved post-intervention (4.57% points [SD 4.45], Motor cortical activation during non-dominant ankle dorsiflexion is a modest indicator of the potential for gross motor skill change. Further investigation of patterns of neuroplastic change will improve our understanding of effects. NCT02584491 and NCT02754128.
Sections du résumé
BACKGROUND
Gross motor intervention designs for children with diplegic cerebral palsy (DCP) require an improved understanding of the children's potential for neuroplasticity.
OBJECTIVE
To identify relations between functional neuroplasticity and motor skill changes following gross motor interventions for children with DCP.
METHODS
There were 17 participants with DCP (ages 8-16 years; 6 females; Gross Motor Function Classification System Level I [n = 9] and II [n = 8]). Each completed a 6-week gross motor intervention program that was directed toward achievement of individualized motor/physical activity goals. Outcomes were assessed pre/post and 4 to 6 months post-intervention (follow-up). An active ankle dorsiflexion task was completed during functional magnetic resonance imaging. The ratio of motor cortical activation volume in each hemisphere was calculated using a laterality index. The
RESULTS
Challenge scores improved post-intervention (4.57% points [SD 4.45],
CONCLUSIONS
Motor cortical activation during non-dominant ankle dorsiflexion is a modest indicator of the potential for gross motor skill change. Further investigation of patterns of neuroplastic change will improve our understanding of effects.
CLINICALTRIALS.GOV REGISTRY
NCT02584491 and NCT02754128.
Identifiants
pubmed: 36524254
doi: 10.1177/15459683221143503
pmc: PMC9896542
doi:
Banques de données
ClinicalTrials.gov
['NCT02584491', 'NCT02754128']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-26Références
Dev Med Child Neurol. 2008 Oct;50(10):744-50
pubmed: 18834387
J Neuroeng Rehabil. 2013 Jun 15;10(1):57
pubmed: 23767869
Dev Med Child Neurol. 2009 Aug;51(8):607-14
pubmed: 19220390
Res Dev Disabil. 2015 Aug-Sep;43-44:136-49
pubmed: 26183338
Psychol Bull. 1988 Mar;103(2):179-92
pubmed: 3283813
Disabil Rehabil. 2022 Aug;44(16):4485-4492
pubmed: 33955308
Int J Dev Neurosci. 2018 May;66:54-62
pubmed: 29413879
Magn Reson Imaging. 2008 Jun;26(5):594-601
pubmed: 18158224
Phys Occup Ther Pediatr. 2012 Nov;32(4):368-82
pubmed: 22954372
Int J Dev Neurosci. 2017 May;58:17-25
pubmed: 28130065
Clin Neurophysiol. 2012 Jul;123(7):1383-90
pubmed: 22153667
Neuroimage. 2004 Sep;23(1):370-81
pubmed: 15325385
Neurophotonics. 2020 Oct;7(4):045001
pubmed: 33062800
Front Neurol. 2021 May 03;12:660780
pubmed: 34012418
Cogn Behav Neurol. 2014 Dec;27(4):183-8
pubmed: 25539037
Front Hum Neurosci. 2020 May 25;14:159
pubmed: 32528261
Neural Plast. 2015;2015:798481
pubmed: 26640717
Phys Occup Ther Pediatr. 2018 Nov;38(4):382-394
pubmed: 28922044
Pediatr Neurol. 2009 Sep;41(3):171-8
pubmed: 19664531
Neuroimage. 2004 Aug;22(4):1619-27
pubmed: 15275918
Front Rehabil Sci. 2022 Apr 05;3:811509
pubmed: 36189020
J Pediatr Health Care. 2007 May-Jun;21(3):146-52
pubmed: 17478303
Dev Med Child Neurol. 2011 Sep;53 Suppl 4:56-61
pubmed: 21950396
Front Pediatr. 2016 Jan 06;3:112
pubmed: 26779464
Brain Dev. 2013 Aug;35(7):647-53
pubmed: 23165172
Dev Med Child Neurol. 2013 Oct;55(10):885-910
pubmed: 23962350
Disabil Rehabil. 2022 Jun;44(13):3039-3047
pubmed: 33353440
Brain. 2011 Apr;134(Pt 4):1199-210
pubmed: 21385750
Res Dev Disabil. 2014 Nov;35(11):2840-8
pubmed: 25105567
Neurorehabil Neural Repair. 2019 Jan;33(1):59-69
pubmed: 30595088
Dev Med Child Neurol. 2008 Apr;50(4):283-9
pubmed: 18312423
Front Hum Neurosci. 2020 Jul 09;14:275
pubmed: 32733223
Dev Med Child Neurol. 2006 Oct;48(10):797-803
pubmed: 16978458
J Child Neurol. 2009 Oct;24(10):1230-5
pubmed: 19805822
Cereb Cortex. 2007 Aug;17(8):1906-17
pubmed: 17060367
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Med Educ. 2009 May;43(5):495-6
pubmed: 19422516
Front Hum Neurosci. 2021 Mar 15;15:598800
pubmed: 33790748
Neuroimage Clin. 2018 Jul 30;20:275-285
pubmed: 30101059
Arch Phys Med Rehabil. 2009 Mar;90(3):447-53
pubmed: 19254610
Front Hum Neurosci. 2014 Aug 01;8:594
pubmed: 25136312
Dev Med Child Neurol. 2009 Oct;51 Suppl 4:134-9
pubmed: 19740221
BMC Pediatr. 2013 Oct 11;13:168
pubmed: 24112817
Eur J Paediatr Neurol. 2020 Jul;27:49-59
pubmed: 32417186
Somatosens Mot Res. 2009 Dec;26(4):90-104
pubmed: 20047510
Dev Med Child Neurol. 2017 Jan;59(1):57-64
pubmed: 27325153
BMC Neurol. 2015 Oct 08;15:188
pubmed: 26449859
Can J Occup Ther. 1990 Apr;57(2):82-7
pubmed: 10104738
Phys Occup Ther Pediatr. 2021;41(4):372-389
pubmed: 33342345
Curr Neurol Neurosci Rep. 2020 Feb 21;20(2):3
pubmed: 32086598
Neurorehabil Neural Repair. 2020 Jun;34(6):533-546
pubmed: 32407247
J Child Neurol. 2007 Nov;22(11):1281-7
pubmed: 18006957
Neurorehabil Neural Repair. 2016 Oct;30(9):834-44
pubmed: 26867559
Neural Plast. 2013;2013:356275
pubmed: 24367726
Stroke. 2009 Jul;40(7):2460-7
pubmed: 19461018
Dev Med Child Neurol. 2009 Sep;51(9):697-704
pubmed: 19416315
PLoS One. 2014 Aug 29;9(8):e105777
pubmed: 25171216
Dev Med Child Neurol. 2010 Mar;52(3):264-9
pubmed: 20089048
Dev Med Child Neurol. 2007 Jan;49(1):39-44
pubmed: 17209975
Clin Rehabil. 2015 Dec;29(12):1212-23
pubmed: 25604912
Neurorehabil Neural Repair. 2017 Aug;31(8):736-745
pubmed: 28691601