Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels.
Journal
The Journal of general physiology
ISSN: 1540-7748
Titre abrégé: J Gen Physiol
Pays: United States
ID NLM: 2985110R
Informations de publication
Date de publication:
06 02 2023
06 02 2023
Historique:
entrez:
16
12
2022
pubmed:
17
12
2022
medline:
21
12
2022
Statut:
ppublish
Résumé
Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085) provide unprecedented visualization of K+ conduction through open Kir2.2 channels and of the molecular details of channel block by spermine.
Identifiants
pubmed: 36524992
pii: 213764
doi: 10.1085/jgp.202213144
pmc: PMC9764022
pii:
doi:
Substances chimiques
Spermine
2FZ7Y3VOQX
Polyamines
0
Potassium Channel Blockers
0
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : R03 TR003670
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140024
Pays : United States
Organisme : NIH HHS
ID : HL140024
Pays : United States
Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2022 Lee and Nichols.
Références
Nature. 2011 Aug 28;477(7365):495-8
pubmed: 21874019
J Gen Physiol. 1999 Jan;113(1):35-43
pubmed: 9874686
Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):
pubmed: 34815345
J Biol Chem. 2018 Nov 30;293(48):18779-18788
pubmed: 30333230
Nature. 1994 Sep 15;371(6494):246-9
pubmed: 8078584
J Gen Physiol. 1995 Nov;106(5):923-55
pubmed: 8648298
Nat Struct Mol Biol. 2012 Jan 08;19(2):158-63
pubmed: 22231399
J Gen Physiol. 2020 Jan 6;152(1):
pubmed: 31744859
Front Pharmacol. 2020 May 15;11:721
pubmed: 32499707
J Gen Physiol. 2010 May;135(5):495-508
pubmed: 20421374
Science. 1998 Apr 3;280(5360):69-77
pubmed: 9525859
Annu Rev Physiol. 1997;59:171-91
pubmed: 9074760
Neuron. 2001 Mar;29(3):657-67
pubmed: 11301025
Channels (Austin). 2007 May-Jun;1(3):172-8
pubmed: 18690029
J Gen Physiol. 2003 Apr;121(4):261-75
pubmed: 12642596
J Gen Physiol. 2019 Oct 7;151(10):1231-1246
pubmed: 31511304
J Gen Physiol. 2016 Sep;148(3):227-37
pubmed: 27527100
J Gen Physiol. 2023 Feb 6;155(2):
pubmed: 36524993
J Physiol. 2003 Jul 1;550(Pt 1):67-82
pubmed: 12740427
J Gen Physiol. 1998 Sep;112(3):351-63
pubmed: 9725894
J Gen Physiol. 2004 Nov;124(5):541-54
pubmed: 15477380
Science. 2009 Dec 18;326(5960):1668-74
pubmed: 20019282