Chronic Ethanol Exposure Modulates Periaqueductal Gray to Extended Amygdala Dopamine Circuit.

Mice Male Animals Periaqueductal Gray Ethanol / toxicity Dopamine / pharmacology Amygdala Neurons / physiology Mice, Transgenic

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
01 02 2023
Historique:
received: 09 06 2022
revised: 29 11 2022
accepted: 01 12 2022
pubmed: 17 12 2022
medline: 4 2 2023
entrez: 16 12 2022
Statut: ppublish

Résumé

The bed nucleus of the stria terminalis (BNST) is a component of the extended amygdala that regulates motivated behavior and affective states and plays an integral role in the development of alcohol-use disorder (AUD). The dorsal subdivision of the BNST (dBNST) receives dense dopaminergic input from the ventrolateral periaqueductal gray (vlPAG)/dorsal raphe (DR). To date, no studies have examined the effects of chronic alcohol on this circuit. Here, we used chronic intermittent ethanol exposure (CIE), a well-established rodent model of AUD, to functionally interrogate the vlPAG/DR-BNST dopamine (DA) circuit during acute withdrawal. We selectively targeted vlPAG/DR

Identifiants

DOI: 10.1523/JNEUROSCI.1219-22.2022 PMID: 36526372 PMC: PMC9899080
pubmed: 36526372
pii: JNEUROSCI.1219-22.2022
doi: 10.1523/JNEUROSCI.1219-22.2022
pmc: PMC9899080
doi:

Substances chimiques

Ethanol 3K9958V90M
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

709-721

Subventions

Organisme : NIAAA NIH HHS
ID : P60 AA011605
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007573
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA027460
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122230
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026363
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA019454
Pays : United States

Informations de copyright

Copyright © 2023 the authors.

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Auteurs

Dipanwita Pati (D)

Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2751.

Anthony M Downs (AM)

Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2751.

Zoe A McElligott (ZA)

Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2751.
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2751.
ORCID: 0000-0002-4717-5698

Thomas L Kash (TL)

Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 tkash@email.unc.edu.
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2751.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Substance grise centrale du mésencéphale › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Cellules › Neurones › Chronic Ethanol Exposure Modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Chronic Ethanol Exposure Modulates...