Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus.
EEEV
RNA replicase
RNA replication
alpavirus
template RNA
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 01 2023
31 01 2023
Historique:
pubmed:
20
12
2022
medline:
3
2
2023
entrez:
19
12
2022
Statut:
ppublish
Résumé
Eastern equine encephalitis virus (EEEV) usually cycles between Culiseta melanura mosquitoes and birds; however, it can also infect humans. EEEV has a positive-sense RNA genome that, in infected cells, serves as an mRNA for the P1234 polyprotein. P1234 undergoes a series of precise cleavage events producing four nonstructural proteins (nsP1-4) representing subunits of the RNA replicase. Here, we report the construction and properties of a
Identifiants
pubmed: 36533950
doi: 10.1128/jvi.01368-22
pmc: PMC9888243
doi:
Substances chimiques
RNA, Viral
0
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0136822Subventions
Organisme : Medical Research Council
ID : MC_PC_16028
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200171/Z/15/Z
Pays : United Kingdom
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