Normative Values for Body Surface Gastric Mapping Evaluations of Gastric Motility Using Gastric Alimetry: Spectral Analysis.
Journal
The American journal of gastroenterology
ISSN: 1572-0241
Titre abrégé: Am J Gastroenterol
Pays: United States
ID NLM: 0421030
Informations de publication
Date de publication:
01 06 2023
01 06 2023
Historique:
received:
25
07
2022
accepted:
06
10
2022
medline:
2
6
2023
pubmed:
20
12
2022
entrez:
19
12
2022
Statut:
ppublish
Résumé
Body surface gastric mapping (BSGM) is a new noninvasive test of gastric function. BSGM offers several novel and improved biomarkers of gastric function capable of differentiating patients with overlapping symptom profiles. The aim of this study was to define normative reference intervals for BSGM spectral metrics in a population of healthy controls. BSGM was performed in healthy controls using Gastric Alimetry (Alimetry, New Zealand) comprising a stretchable high-resolution array (8 × 8 electrodes; 196 cm 2 ), wearable Reader, and validated symptom-logging App. The evaluation encompassed a fasting baseline (30 minutes), 482 kCal meal, and 4-hour postprandial recording. Normative reference intervals were calculated for BSGM metrics including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index (a measure of the concentration of power in the gastric frequency band over time), body mass index (BMI)-adjusted amplitude (μV), and fed:fasted amplitude ratio. Data were reported as median and reference interval (5th and/or 95th percentiles). A total of 110 subjects (55% female, median age 32 years [interquartile range 24-50], median BMI 23.8 kg/m 2 [interquartile range 21.4-26.9]) were included. The median Principal Gastric Frequency was 3.04 cycles per minute; reference interval: 2.65-3.35 cycles per minute. The median Gastric Alimetry Rhythm Index was 0.50; reference interval: ≥0.25. The median BMI-adjusted amplitude was 37.6 μV; reference interval: 20-70 μV. The median fed:fasted amplitude ratio was 1.85; reference interval ≥1.08. A higher BMI was associated with a shorter meal-response duration ( P = 0.014). This study provides normative reference intervals for BSGM spectral data to inform diagnostic interpretations of abnormal gastric function.
Identifiants
pubmed: 36534985
doi: 10.14309/ajg.0000000000002077
pii: 00000434-202306000-00025
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1047-1057Subventions
Organisme : NIDDK NIH HHS
ID : R56 DK126935
Pays : United States
Informations de copyright
Copyright © 2022 by The American College of Gastroenterology.
Références
Aziz I, Palsson OS, Whitehead WE, et al. Epidemiology, clinical characteristics, and associations for Rome IV functional nausea and vomiting disorders in adults. Clin Gastroenterol Hepatol 2019;17(5):878–86.
Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study. Gastroenterology 2021;160(1):99–114.e3.
Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002;122(5):1500–11.
Harer KN, Pasricha PJ. Chronic unexplained nausea and vomiting or gastric neuromuscular dysfunction (GND)? An update on nomenclature, pathophysiology and treatment, and relationship to gastroparesis. Curr Treat Options Gastroenterol 2016;14(4):410–9.
Pasricha PJ, Grover M, Yates KP, et al. Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathologic features. Gastroenterology 2021;160(6):2006–17.
Pasricha PJ, Colvin R, Yates K, et al. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol 2011;9(7):567–76.e4.
Camilleri M, Chedid V. Actionable biomarkers: The key to resolving disorders of gastrointestinal function. Gut 2020;69(10):1730–7.
Carson DA, O'Grady G, Du P, et al. Body surface mapping of the stomach: New directions for clinically evaluating gastric electrical activity. Neurogastroenterol Motil 2021;33(3):e14048.
Gharibans AA, Coleman TP, Mousa H, et al. Spatial patterns from high-resolution electrogastrography correlate with severity of symptoms in patients with functional dyspepsia and gastroparesis. Clin Gastroenterol Hepatol 2019;17(13):2668–77.
Gharibans AA, Hayes TCL, Carson DA, et al. A novel scalable electrode array and system for non-invasively assessing gastric function using flexible electronics. Neurogastroenterol Motil 2022;14:e14418.
Gharibans AA, Calder S, Varghese C, et al. Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a novel non-invasive gastric mapping device. medRxiv 2022.
Calder S, Schamberg G, Varghese C, et al. An automated artifact detection and rejection system for body surface gastric mapping. Neurogastroenterol Motil 2022;34(11):e14421.
Somarajan S, Muszynski ND, Olson JD, et al. The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children. Neurogastroenterol Motil 2021;33(5):e14035.
Sebaratnam G, Karulkar N, Calder S, et al. Standardized system and App for continuous patient symptom logging in gastroduodenal disorders: Design, implementation, and validation. Neurogastroenterol Motil 2022;34(8):e14331.
Schamberg G, Varghese C, Calder S, et al. Revised spectral metrics for body surface measurements of gastric electrophysiology. medRxiv 2022.
Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. PLoS Med 2007;4(10):e297.
Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology 2016;150(6):1380–92.
Zhu H, Chen JDZ. Gastric distension alters frequency and regularity but not amplitude of the gastric slow wave. Neurogastroenterol Motil 2004;16(6):745–52.
Smout AJPM, Van der Schee EJ, Grashuis JL. What is measured in electrogastrography? Dig Dis Sci 1980;25(3):179–87.
Yin J, Chen JDZ. Electrogastrography, methodology, validation and applications. J Neurogastroenterol Motil 2013;19:5–17.
Koch KL, Stern RM. Handbook of electrogastrography. Oxford University Press: Oxford, UK, 2004.
O'Grady G, Gharibans AA, Du P, et al. The gastric conduction system in health and disease: A translational review. Am J Physiol Gastrointest Liver Physiol 2021;321(5):G527–42.
Du P, O'Grady G, Cheng LK, et al. A multiscale model of the electrophysiological basis of the human electrogastrogram. Biophys J 2010;99(9):2784–92.
Calder S, O'Grady G, Cheng LK, et al. Torso-tank validation of high-resolution electrogastrography (EGG): Forward modelling, methodology and results. Ann Biomed Eng 2018;46(8):1183–93.
Tougas G, Eaker EY, Abell TL, et al. Assessment of gastric emptying using a low fat meal: Establishment of international control values. Am J Gastroenterol 2000;95(6):1456–62.
Bredenoord AJ, Rancati F, Lin H, et al. Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis. Neurogastroenterol Motil 2022;34(11):e14419.
Hyndman RJ, Fan Y. Sample quantiles in statistical packages. Am Statistic 1996;50(4):361–5.
Carson DA, Bhat S, Hayes TCL, et al. Abnormalities on electrogastrography in nausea and vomiting syndromes: A systematic review, meta-analysis, and comparison to other gastric disorders. Dig Dis Sci 2021;67(3):773–85.
Varghese C, Carson DA, Bhat S, et al. Clinical associations of functional dyspepsia with gastric dysrhythmia on electrogastrography: A comprehensive systematic review and meta-analysis. Neurogastroenterol Motil 2021;33(12):e14151.
Bhat S, Varghese C, Carson DA, et al. Gastric dysrhythmia in gastroesophageal reflux disease: A systematic review and meta-analysis. Esophagus 2021;18(3):425–35.
Bhat S, Varghese C, Carson DA, et al. Electrogastrography abnormalities in pediatric gastroduodenal disorders: A systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 2021;73(1):9–16.
Bortolotti M. Electrogastrography, a seductive promise, only partially kept. Am J Gastroenterol 1998:93:1791–4.
Lacy BE, Crowell MD, Cangemi DJ, et al. Diagnostic evaluation of gastric motor and sensory disorders. Am J Gastroenterol 2021;116(12):2345–56.
Parkman HP, Hasler WL, Barnett JL, et al.; American Motility Society Clinical GI Motility Testing Task Force. Electrogastrography: A document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force. Neurogastroenterol Motil 2003;15(2):89–102.
Sukasem A, Calder S, Angeli-Gordon TR, et al. In vivo experimental validation of detection of gastric slow waves using a flexible multichannel electrogastrography sensor linear array. BioMedical Eng Online 2022;21(1):43.
Erickson JC, Bruce LE, Taylor A, et al. Electrocolonography: Non-invasive detection of colonic cyclic motor activity from multielectrode body surface recordings. IEEE Trans Biomed Eng 2020;67(6):1628–37.
Simonian HP, Panganamamula K, Parkman HP, et al. Multichannel electrogastrography (EGG) in normal subjects: A multicenter study. Dig Dis Sci 2004;49:594–601.
Somarajan S, Cassilly S, Obioha C, et al. Effects of body mass index on gastric slow wave: A magnetogastrographic study. Physiol Meas 2014;35(2):205–15.
Brzana RJ, Koch KL, Bingaman S. Gastric myoelectrical activity in patients with gastric outlet obstruction and idiopathic gastroparesis. Am J Gastroenterol 1998;93(10):1803–9.
Camhi SM, Bray GA, Bouchard C, et al. The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: Sex and race differences. Obesity (Silver Spring) 2011;19(2):402–8.
Nederkoorn C, Smulders FT, Jansen A. Cephalic phase responses, craving and food intake in normal subjects. Appetite 2000;35(1):45–55.
Deloose E, Janssen P, Depoortere I, et al. The migrating motor complex: Control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol 2012;9(5):271–85.
Gharibans AA, Smarr BL, Kunkel DC, et al. Artifact rejection methodology enables continuous, noninvasive measurement of gastric myoelectric activity in ambulatory subjects. Sci Rep 2018;8(1):5019.
Xing J, Chen JDZ. Alterations of gastrointestinal motility in obesity. Obes Res 2004;12(11):1723–32.
Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8(12):728–42.
Xu X, Chen DD, Yin J, et al. Altered postprandial responses in gastric myoelectrical activity and cardiac autonomic functions in healthy obese subjects. Obes Surg 2014;24(4):554–60.
Calder S, Cheng LK, Andrews CN, et al. Validation of non-invasive body-surface gastric mapping for detecting electrophysiological biomarkers by simultaneous high-resolution serosal mapping in a porcine model. bioRxiv 2021.