Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.
connectome
genetics
heritability
individual differences
resting state fMRI
sex differences
twins
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
revised:
16
04
2022
received:
18
03
2021
accepted:
19
04
2022
medline:
3
10
2023
pubmed:
21
12
2022
entrez:
20
12
2022
Statut:
ppublish
Résumé
We propose a unique, minimal assumption, approach based on variance analyses (compared with standard approaches) to investigate genetic influence on individual differences on the functional connectivity of the brain using 65 monozygotic and 65 dizygotic healthy young adult twin pairs' low-frequency oscillation resting state functional Magnetic Resonance Imaging (fMRI) data from the Human Connectome Project. Overall, we found high number of genetically-influenced functional (GIF) connections involving posterior to posterior brain regions (occipital/temporal/parietal) implicated in low-level processes such as vision, perception, motion, categorization, dorsal/ventral stream visuospatial, and long-term memory processes, as well as high number across midline brain regions (cingulate) implicated in attentional processes, and emotional responses to pain. We found low number of GIF connections involving anterior to anterior/posterior brain regions (frontofrontal > frontoparietal, frontotemporal, frontooccipital) implicated in high-level processes such as working memory, reasoning, emotional judgment, language, and action planning. We found very low number of GIF connections involving subcortical/noncortical networks such as basal ganglia, thalamus, brainstem, and cerebellum. In terms of sex-specific individual differences, individual differences in males were more genetically influenced while individual differences in females were more environmentally influenced in terms of the interplay of interactions of Task positive networks (brain regions involved in various task-oriented processes and attending to and interacting with environment), extended Default Mode Network (a central brain hub for various processes such as internal monitoring, rumination, and evaluation of self and others), primary sensorimotor systems (vision, audition, somatosensory, and motor systems), and subcortical/noncortical networks. There were >8.5-19.1 times more GIF connections in males than females. These preliminary (young adult cohort-specific) findings suggest that individual differences in the resting state brain may be more genetically influenced in males and more environmentally influenced in females; furthermore, standard approaches may suggest that it is more substantially nonadditive genetics, rather than additive genetics, which contribute to the differences in sex-specific individual differences based on this young adult (male and female) specific cohort. Finally, considering the preliminary cohort-specific results, based on standard approaches, environmental influences on individual differences may be substantially greater than that of genetics, for either sex, frontally and brain-wide. [Correction added on 10 May 2023, after first online publication: added: functional Magnetic Resonance Imaging. Added: individual differences in, twice. Added statement between furthermore … based on standard approaches.].
Identifiants
pubmed: 36537283
doi: 10.1002/hbm.25947
pmc: PMC10543121
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
5238-5293Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB027087
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117568
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002375
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105646
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG051216
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063849
Pays : United States
Informations de copyright
© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Int J Sci Educ. 2008 Jun;30(8):1003
pubmed: 20111670
Nat Neurosci. 2000 Jan;3(1):85-90
pubmed: 10607400
Front Hum Neurosci. 2013 Oct 08;7:650
pubmed: 24115929
JAMA Psychiatry. 2013 Apr;70(4):373-82
pubmed: 23389382
Brain. 1992 Dec;115 ( Pt 6):1783-806
pubmed: 1486461
Pediatrics. 2014 Dec;134(6):e1603-10
pubmed: 25367542
Brain Res. 2006 Mar 24;1079(1):25-35
pubmed: 16507301
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4507-12
pubmed: 18347338
Hum Brain Mapp. 2021 Dec 15;42(18):5943-5955
pubmed: 34520078
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1223-8
pubmed: 20133824
Hum Biol. 2003 Aug;75(4):539-58
pubmed: 14655876
Dev Cogn Neurosci. 2014 Jul;9:68-81
pubmed: 24552989
Hum Mov Sci. 2007 Aug;26(4):590-616
pubmed: 17706312
Behav Genet. 2019 Jan;49(1):99-111
pubmed: 30569348
Neuroimage. 2015 Apr 1;109:12-26
pubmed: 25579447
Hum Genet. 1996 Mar;97(3):319-23
pubmed: 8786073
Antioxid Redox Signal. 2011 May 15;14(10):2013-54
pubmed: 20649473
Multimodal Brain Image Anal (2011). 2011;2011:35-43
pubmed: 25346947
Behav Genet. 2018 Mar;48(2):147-154
pubmed: 29264815
Brain Struct Funct. 2015 Mar;220(2):1031-49
pubmed: 24399179
Cereb Cortex. 2005 Jun;15(6):681-95
pubmed: 15342430
Neuroimage. 2015 Jul 15;115:235-44
pubmed: 25887261
Ann N Y Acad Sci. 2015 Sep;1349:64-82
pubmed: 26348486
Soc Cogn Affect Neurosci. 2014 Sep;9(9):1388-94
pubmed: 24036962
Arch Womens Ment Health. 2019 Apr;22(2):289-299
pubmed: 30008085
Elife. 2017 Jul 26;6:
pubmed: 28745584
J Cogn Neurosci. 2012 Aug;24(8):1742-52
pubmed: 22452556
Drug Alcohol Depend. 2012 Oct 1;125(3):252-9
pubmed: 22459914
Nat Rev Neurosci. 2001 Nov;2(11):820-9
pubmed: 11715058
Trends Cogn Sci. 2009 Apr;13(4):175-81
pubmed: 19223226
Sci Rep. 2018 Dec 4;8(1):17624
pubmed: 30514932
Neuroimage. 2017 Mar 1;148:8-19
pubmed: 28065848
Front Integr Neurosci. 2012 May 03;6:17
pubmed: 22563310
Neuropsychopharmacology. 2016 Sep;41(10):2521-9
pubmed: 27091382
Front Psychol. 2015 Oct 31;6:1610
pubmed: 26582995
Wiley Interdiscip Rev Cogn Sci. 2017 Jan;8(1-2):
pubmed: 27906501
Psychometrika. 2016 Jun;81(2):535-49
pubmed: 25622929
Neuroscientist. 2017 Apr;23(2):169-184
pubmed: 26929236
Neurology. 2004 Nov 9;63(9):1591-9
pubmed: 15534241
Nat Genet. 2021 May;53(5):663-671
pubmed: 33888908
Psychol Sci. 2008 Jul;19(7):642-4
pubmed: 18727776
J Speech Lang Hear Res. 2012 Apr;55(2):541-53
pubmed: 22199206
J Neurochem. 2021 May;157(4):963-981
pubmed: 33025572
Brain. 2010 Mar;133(Pt 3):868-79
pubmed: 20061325
Genome Biol. 2018 Jan 9;19(1):2
pubmed: 29310692
J Neurosci. 2006 Jul 12;26(28):7328-36
pubmed: 16837579
Neuroimage. 2014 Nov 15;102 Pt 2:424-34
pubmed: 25132021
Neuropsychol Rev. 2015 Mar;25(1):27-46
pubmed: 25672928
J Cogn Neurosci. 2005 Aug;17(8):1306-15
pubmed: 16197685
PLoS Biol. 2008 Jul 1;6(7):e159
pubmed: 18597554
Cereb Cortex. 2016 May;26(5):2341-2352
pubmed: 26891986
Elife. 2019 Jan 08;8:
pubmed: 30616717
Value Health. 2017 Feb;20(2):200-205
pubmed: 28237195
Neuroimage. 2016 Jan 1;124(Pt B):1102-1107
pubmed: 25934470
Soc Cogn Affect Neurosci. 2011 Jun;6(3):260-9
pubmed: 20478834
Psychon Bull Rev. 2012 Oct;19(5):864-70
pubmed: 22806448
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Am J Clin Nutr. 2005 Mar;81(3):564-9
pubmed: 15755823
JAMA Pediatr. 2014 Nov;168(11):1045-53
pubmed: 25222633
Neuroimage. 2013 Oct 15;80:62-79
pubmed: 23684880
Behav Brain Sci. 2001 Oct;24(5):849-78; discussion 878-937
pubmed: 12239891
Am J Hum Genet. 2016 May 5;98(5):898-908
pubmed: 27132594
Soc Sci Res. 2014 Jan;43:184-99
pubmed: 24267761
Brain Lang. 2006 Aug;98(2):150-8
pubmed: 16716389
Clin Epigenetics. 2021 Feb 15;13(1):35
pubmed: 33588926
Neurosci Lett. 1992 May 25;139(2):257-60
pubmed: 1608556
Neuron. 2004 Jul 22;43(2):271-82
pubmed: 15260962
Neuron. 2009 Sep 10;63(5):568-83
pubmed: 19755101
Genome Res. 2009 Sep;19(9):1639-45
pubmed: 19541911
Twin Res Hum Genet. 2019 Feb;22(1):27-41
pubmed: 30944056
Neuropsychopharmacology. 2023 May;48(6):936-945
pubmed: 36869233
Pharm Stat. 2012 Jul-Aug;11(4):300-9
pubmed: 22588983
Behav Genet. 2005 Nov;35(6):707-21
pubmed: 16273321
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9
pubmed: 16009939
Brain Sci. 2021 Jan 28;11(2):
pubmed: 33525512
Arthritis Res Ther. 2016 Feb 11;18:46
pubmed: 26864139
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Behav Genet. 2021 May;51(3):223-236
pubmed: 33582897
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255
pubmed: 30718410
Pac Symp Biocomput. 2018;23:307-318
pubmed: 29218892
Proc Biol Sci. 2009 Jul 22;276(1667):2675-83
pubmed: 19403538
Neuroimage. 2018 May 15;172:291-312
pubmed: 29307608
Brain Res. 2006 Mar 24;1079(1):57-65
pubmed: 16480695
J Neurosci. 2011 Jul 27;31(30):10882-90
pubmed: 21795540
Neuroimage. 2013 Oct 15;80:144-68
pubmed: 23702415
Neuroimage. 2020 Jan 1;204:116122
pubmed: 31470127
Nicotine Tob Res. 2017 Apr 01;19(4):452-459
pubmed: 27613921
Annu Rev Neurosci. 2001;24:167-202
pubmed: 11283309
Am J Hum Genet. 2015 Nov 5;97(5):708-14
pubmed: 26544805
Front Hum Neurosci. 2013 Oct 10;7:666
pubmed: 24124416
Aging Ment Health. 2022 Mar;26(3):493-498
pubmed: 33295797
Neuroimage. 2012 Oct 1;62(4):2281-95
pubmed: 22326834
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18688-93
pubmed: 20956297
Nat Genet. 2021 Sep;53(9):1283-1289
pubmed: 34493869
Sci Rep. 2020 Jan 30;10(1):10
pubmed: 32001736
Neuropsychopharmacology. 2019 Jan;44(1):71-85
pubmed: 29930385
Behav Genet. 2011 Mar;41(2):329-39
pubmed: 20703791
Hum Brain Mapp. 2023 Nov;44(16):5238-5293
pubmed: 36537283
Nature. 2004 Jun 24;429(6994):883-91
pubmed: 15190254
Front Hum Neurosci. 2019 Oct 17;13:369
pubmed: 31680919
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Front Hum Neurosci. 2020 Jul 21;14:244
pubmed: 32792927
Neuroimage. 2019 Apr 1;189:516-532
pubmed: 30708106
Physiol Rev. 2008 Jan;88(1):91-124
pubmed: 18195084
Am J Phys Anthropol. 1990 Jul;82(3):257-65
pubmed: 2375378
Sleep. 2015 Jan 01;38(1):109-18
pubmed: 25325458
Neuron. 2003 Jan 23;37(2):361-7
pubmed: 12546829
Stat Med. 2020 Nov 30;39(27):3897-3913
pubmed: 32449216
Neuroimage. 2001 Aug;14(2):510-20
pubmed: 11467923
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 May;1(3):278-287
pubmed: 27141532
Cogn Psychol. 1997 Jun;33(1):43-63
pubmed: 9212721
Brain. 2004 Oct;127(Pt 10):2316-30
pubmed: 15269116
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Curr Biol. 2017 Jun 19;27(12):R580-R586
pubmed: 28633023
Hum Brain Mapp. 2015 Oct;36(10):3959-72
pubmed: 26147340
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
Science. 2009 Mar 27;323(5922):1737-40
pubmed: 19325117
Twin Res. 2003 Oct;6(5):361-76
pubmed: 14624720
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
Biol Psychiatry. 2022 Jan 1;91(1):102-117
pubmed: 34099189
F1000Res. 2018 Jun 20;7:
pubmed: 29983911
J Neurosci. 2009 Jul 1;29(26):8586-94
pubmed: 19571149
Annu Rev Neurosci. 1986;9:357-81
pubmed: 3085570
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
Behav Genet. 2015 Mar;45(2):157-70
pubmed: 25690561
Neuropsychology. 2001 Jan;15(1):115-27
pubmed: 11216882
Genome Biol. 2016 Jul 29;17(1):166
pubmed: 27473438
Neuroimage. 2013 Dec;83:550-8
pubmed: 23747458
Neuroimage. 2022 Apr 15;250:118877
pubmed: 35051581
Brain. 2014 Jan;137(Pt 1):12-32
pubmed: 23869106
Front Hum Neurosci. 2019 Apr 05;13:104
pubmed: 31024276
Am J Clin Nutr. 2013 Nov;98(5):1317-25
pubmed: 24047914
Genetics. 2020 Jun;215(2):343-357
pubmed: 32291292
Annu Rev Neurosci. 2004;27:279-306
pubmed: 15217334
Soc Cogn Affect Neurosci. 2016 Nov;11(11):1792-1801
pubmed: 27405616
Twin Res Hum Genet. 2005 Jun;8(3):201-13
pubmed: 15989748
Brain Lang. 2009 May-Jun;109(2-3):133-40
pubmed: 19250662
Neuroimage. 2019 Nov 15;202:116073
pubmed: 31386921