Preparation and identification of isoquinoline alkaloids with ATP citrate lyase inhibitory activity from Dactylicapnos scandens.

Alkaloids / pharmacology ATP Citrate (pro-S)-Lyase Circular Dichroism Isoquinolines / pharmacology Molecular Structure Papaveraceae / chemistry
ACLY inhibitory activity Dactylicapnos scandens Isoquinoline alkaloids Papaveraceae

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Mar 2023
Historique:
received: 16 11 2022
revised: 16 12 2022
accepted: 16 12 2022
pubmed: 21 12 2022
medline: 11 2 2023
entrez: 20 12 2022
Statut: ppublish

Résumé

Three new isoquinoline alkaloids including a morphine derivative (1), two aporphine alkaloids (2-3), together with five known alkaloids (4-8) were obtained from the extract of Dactylicapnos scandens (D.Don) Hutch. (D. scandens). Their structures and absolute configurations were elucidated by extensive spectroscopic data analysis including HRESIMS, NMR and electronic circular dichroism (ECD) and ECD calculation. Compounds 1-8 were evaluated for ATP Citrate Lyase (ACLY) inhibitory activity through an enzymatic assay. Among them, 2 and 3 showed the high ACLY inhibitory activity with an IC

Identifiants

DOI: 10.1016/j.fitote.2022.105397 PMID: 36539068
pubmed: 36539068
pii: S0367-326X(22)00275-1
doi: 10.1016/j.fitote.2022.105397
pii:
doi:

Substances chimiques

Alkaloids 0
ATP Citrate (pro-S)-Lyase EC 2.3.3.8
Isoquinolines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105397

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declared that they have no conflict of interest to this work.

Auteurs

Hui Jiang (H)

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.

Tao Hou (T)

DICP-CMC Innovation Institute of Medicine, Taizhou 225300, PR China.

Yan Han (Y)

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China; Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Shu-Bin Lu (SB)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Lei Liu (L)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Ding-Xiang Li (DX)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Yun-Hui Zhu (YH)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Hang Huang (H)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Wen-Jie Li (WJ)

Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

Xiang-Ya Xue (XY)

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China; Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China. Electronic address: xuexy@dicp.ac.cn.

Yan-Fang Liu (YF)

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China; Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China. Electronic address: liuyanfang@dicp.ac.cn.

Xin-Miao Liang (XM)

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China; Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, PR China.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Preparation and identification of isoquinoline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › ATP citrate (pro-S)-lyase › Preparation and identification of isoquinoline...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Preparation and identification of isoquinoline...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Preparation and identification of isoquinoline...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Preparation and identification of isoquinoline...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Ranunculales › Papaveraceae › Preparation and identification of isoquinoline...