Acylphloroglucinol-monoterpene meroterpenoids from Eucalyptus tereticornis and their inhibitory activity against ATP citrate lyase.
(+)-/(−)-eucateretins A−E
ATP citrate Lyase
Eucalyptus tereticornis Smith
Meroterpenoids
Myrtaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
28
06
2022
revised:
16
12
2022
accepted:
17
12
2022
pubmed:
23
12
2022
medline:
4
2
2023
entrez:
22
12
2022
Statut:
ppublish
Résumé
Five undescribed enantiomeric pairs of acylphloroglucinol-monoterpene meroterpenoids ((+)-/(-)-eucateretins A-E) resolved by chiral-phase HPLC were obtained from the leaves of Eucalyptus tereticornis Smith, along with nine known analogues. Their structures were elucidated by spectroscopic methods and ECD calculations. This is the first report of meroterpenoid enantiomers from this plant. Some of the isolates, (-)-eucateretin A, (+)-/(-)-eucateretins E, 7'α-eucalrobusone X, eucalrobusone X, and robustadial B, exhibited inhibitory effects on ATP citrate lyase, and 7'α-eucalrobusone X significantly suppressed the hepatocyte lipogenesis.
Identifiants
pubmed: 36549384
pii: S0031-9422(22)00481-2
doi: 10.1016/j.phytochem.2022.113565
pii:
doi:
Substances chimiques
Monoterpenes
0
ATP Citrate (pro-S)-Lyase
EC 2.3.3.8
Acyltransferases
EC 2.3.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113565Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.