Deciphering the Antifibrotic Property of Metformin.
fibrosis
inflammation
mesenchymal stem cells
metformin
miRs
myofibroblast
oxidative stress
transdifferentiation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 12 2022
16 12 2022
Historique:
received:
10
10
2022
revised:
14
12
2022
accepted:
14
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Fibrosis is a chronic progressive and incurable disease leading to organ dysfunction. It is characterized by the accumulation of extracellular matrix proteins produced by mesenchymal stem cells (MSCs) differentiating into myofibroblasts. Given the complexity of its pathophysiology, the search for effective treatments for fibrosis is of paramount importance. Metformin, a structural dimethyl analog of the galegine guanide extracted from the "French Lilac" (Fabaceae
Identifiants
pubmed: 36552855
pii: cells11244090
doi: 10.3390/cells11244090
pmc: PMC9777391
pii:
doi:
Substances chimiques
Transforming Growth Factor beta1
0
Metformin
9100L32L2N
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
CD248 protein, human
0
Antigens, Neoplasm
0
Antigens, CD
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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