A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility.


Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
16 12 2022
Historique:
received: 15 11 2022
revised: 13 12 2022
accepted: 14 12 2022
entrez: 23 12 2022
pubmed: 24 12 2022
medline: 27 12 2022
Statut: epublish

Résumé

While the role of common genetic variants in multiple sclerosis (MS) has been elucidated in large genome-wide association studies, the contribution of rare variants to the disease remains unclear. Herein, a whole-genome sequencing study in four affected and four healthy relatives of a consanguineous Italian family identified a novel missense c.1801T > C (p.S601P) variant in the

Identifiants

pubmed: 36553660
pii: genes13122392
doi: 10.3390/genes13122392
pmc: PMC9777893
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : MOP-137051
Pays : Canada

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Auteurs

Federica Esposito (F)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Ana Maria Osiceanu (AM)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Melissa Sorosina (M)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Linda Ottoboni (L)

Unit of Neuroimmunology, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

Bryan Bollman (B)

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.

Silvia Santoro (S)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Barbara Bettegazzi (B)

Gene Therapy of Neurodegenerative Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Vita-Salute San Raffaele University, 20132 Milan, Italy.

Andrea Zauli (A)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Ferdinando Clarelli (F)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Elisabetta Mascia (E)

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Andrea Calabria (A)

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), 20132 Milan, Italy.

Daniele Zacchetti (D)

Unit of Cellular Neurophysiology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

Ruggero Capra (R)

Multiple Sclerosis Centre, Spedali Civili di Brescia, 25018 Montichiari, Italy.

Maurizio Ferrari (M)

Vita-Salute San Raffaele University, 20132 Milan, Italy.
Unit of Genomics for Human Disease Diagnosis, Department of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy.

Paolo Provero (P)

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Dejan Lazarevic (D)

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Davide Cittaro (D)

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Paola Carrera (P)

Unit of Genomics for Human Disease Diagnosis, Laboratory of Genetics and Cytogenetics, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Nikolaos Patsopoulos (N)

Department of Neurology, Harvard Institutes of Medicine, Boston, MA 02115, USA.

Daniela Toniolo (D)

Department of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy.

A Dessa Sadovnick (AD)

Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.

Gianvito Martino (G)

Unit of Neuroimmunology, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

Philip L De Jager (PL)

Department of Neurology, Columbia University, New York, NY 10027, USA.

Giancarlo Comi (G)

Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Elia Stupka (E)

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Carles Vilariño-Güell (C)

Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.

Laura Piccio (L)

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Charles Perkin Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Brain and Mind Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW 2050, Australia.

Filippo Martinelli Boneschi (F)

Neurology Unit, ASST Santi Paolo e Carlo, 20142 Milan, Italy.
Department of Health Sciences, University of Milan, 20122 Milan, Italy.

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Classifications MeSH