Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range.
DNA
deuterium
dynamics of a double-stranded DNA molecule
open states
rotational movements of nitrogenous bases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Dec 2022
07 Dec 2022
Historique:
received:
03
11
2022
revised:
02
12
2022
accepted:
03
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single
Identifiants
pubmed: 36555136
pii: ijms232415487
doi: 10.3390/ijms232415487
pmc: PMC9778762
pii:
doi:
Substances chimiques
Deuterium
AR09D82C7G
Hydrogen
7YNJ3PO35Z
Nucleotides
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Kuban Scientific Foundation
ID : Н-21.1/11
Organisme : the state assignment of the SSC RAS
ID : 122020100351-9
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