The Aging Heart: A Molecular and Clinical Challenge.
aging
arrhythmias
cardiomyopathies
elderly
geriatric cardiology
heart failure
inflammation
ischemic cardiomyopathy
microRNAs
molecular mechanisms
oxidative stress
telomeres
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Dec 2022
16 Dec 2022
Historique:
received:
13
10
2022
revised:
05
12
2022
accepted:
07
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Aging is associated with an increasing burden of morbidity, especially for cardiovascular diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure, arrhythmias, and cardiomyopathies present a significant prevalence in older people, and are characterized by peculiar clinical manifestations that have distinct features compared with the same conditions in a younger population. Remarkably, the aging heart phenotype in both healthy individuals and patients with CVD reflects modifications at the cellular level. An improvement in the knowledge of the physiological and pathological molecular mechanisms underlying cardiac aging could improve clinical management of older patients and offer new therapeutic targets.
Identifiants
pubmed: 36555671
pii: ijms232416033
doi: 10.3390/ijms232416033
pmc: PMC9783309
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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