Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model.
cuprizone
demyelination
multiple sclerosis
progression
protection
remyelination
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Dec 2022
17 Dec 2022
Historique:
received:
17
11
2022
revised:
14
12
2022
accepted:
15
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients.
Identifiants
pubmed: 36555733
pii: ijms232416093
doi: 10.3390/ijms232416093
pmc: PMC9783537
pii:
doi:
Substances chimiques
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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