A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5.
KCNE
KCNQ1
LQT5
cardiac arrhythmia
potassium channel
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
13 Dec 2022
13 Dec 2022
Historique:
received:
07
11
2022
revised:
07
12
2022
accepted:
09
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
24
12
2022
Statut:
epublish
Résumé
Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit of the voltage-gated ion channels generating the cardiac potassium current I
Identifiants
pubmed: 36559002
pii: ph15121550
doi: 10.3390/ph15121550
pmc: PMC9782992
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research, Development and Innovation Office
ID : K-135464
Organisme : National Research, Development and Innovation Office
ID : K-128851
Organisme : National Research, Development and Innovation Office
ID : GINOP-2.3.2-15-2016-00006
Organisme : National Research, Development and Innovation Office
ID : TKP2021-EGA-32
Organisme : Ministry of Human Capacities
ID : 20391-3/2018/FEKUSTRAT
Organisme : Ministry of Human Capacities
ID : EFOP-3.6.1-16-2016-00006
Organisme : Ministry of Human Capacities
ID : UNKP-18-4 New National Excellence Program
Organisme : Hungarian Academy of Sciences
ID : János Bolyai Research Scholarship
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