Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats.

Rats Male Humans Animals Prolactin-Releasing Hormone / pharmacology Sleep Deprivation / metabolism Mood Disorders / etiology Quality of Life Rats, Wistar Hypothalamic Hormones / metabolism Sleep / physiology Neurons / physiology Norepinephrine / metabolism
GABA(A) receptor MCH mental disorders sleep stress suicide

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
01 02 2023
Historique:
received: 15 11 2021
revised: 31 08 2022
accepted: 30 09 2022
pubmed: 24 12 2022
medline: 4 2 2023
entrez: 23 12 2022
Statut: ppublish

Résumé

Stress disorders impair sleep and quality of life; however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator; we therefore hypothesized that PrRP may be involved in the development of stress disorders. PrRP is produced by the medullary A1/A2 noradrenaline (NA) cells, which transmit stress signals to forebrain centers, and by non-NA cells in the hypothalamic dorsomedial nucleus. We found in male rats that both PrRP and PrRP-NA cells innervate melanin-concentrating hormone (MCH) producing neurons in the dorsolateral hypothalamus (DLH). These cells serve as a key hub for regulating sleep and affective states.

Identifiants

DOI: 10.1523/JNEUROSCI.2139-21.2022 PMID: 36564184 PMC: PMC9899089
pubmed: 36564184
pii: JNEUROSCI.2139-21.2022
doi: 10.1523/JNEUROSCI.2139-21.2022
pmc: PMC9899089
doi:

Substances chimiques

melanin-concentrating hormone 67382-96-1
Prolactin-Releasing Hormone 0
Hypothalamic Hormones 0
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

846-862

Informations de copyright

Copyright © 2023 Vas et al.

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Auteurs

Szilvia Vas (S)

Department of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Semmelweis University, Budapest, 1089, Hungary.

Rege S Papp (RS)

Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, 1094, Hungary.

Katalin Könczöl (K)

Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.

Emese Bogáthy (E)

Department of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.

Noémi Papp (N)

Department of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.

Csaba Ádori (C)

Department of Neuroscience, Karolinska Institutet, Stockholm, 17177, Sweden.

Máté Durst (M)

Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.

Klaudia Sípos (K)

Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.

Klementina Ocskay (K)

Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.

Imre Farkas (I)

Laboratory of Reproductive Neurobiology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
ORCID: 0000-0002-0159-4408

Flóra Bálint (F)

Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.

Szilamér Ferenci (S)

Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.

Bibiána Török (B)

Laboratory of Behavioral and Stress Studies, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Institute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.

Anita Kovács (A)

Institute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.

Evelin Szabó (E)

Institute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.

Dóra Zelena (D)

Laboratory of Behavioral and Stress Studies, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.
Institute of Physiology, Medical School, University of Pécs, Centre for Neuroscience, Szentágothai Research Center, Pécs, 7624, Hungary.
ORCID: 0000-0001-5616-1100

Krisztina J Kovács (KJ)

Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Budapest, 1083, Hungary.

Anna Földes (A)

Department of Oral Biology, Semmelweis University, Budapest, 1089, Hungary.

Erzsébet Kató (E)

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1089, Hungary.

László Köles (L)

Department of Oral Biology, Semmelweis University, Budapest, 1089, Hungary.
Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1089, Hungary.

György Bagdy (G)

Department of Pharmacodynamics, Semmelweis University, Budapest, 1089, Hungary.
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Semmelweis University, Budapest, 1089, Hungary.
NAP2-SE New Antidepressant Target Research Group, Budapest, 1085, Hungary.

Miklós Palkovits (M)

Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, 1094, Hungary.
Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.

Zsuzsanna E Tóth (ZE)

Laboratory of Neuroendocrinology and In Situ Hybridization, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary toth.zsuzsanna.emese@med.semmelweis-univ.hu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormone de libération de la prolactine › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Privation de sommeil › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Cellules › Neurones › Prolactin-Releasing Peptide Contributes to...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Prolactin-Releasing Peptide Contributes to...