Absence of early platelet increment in healthy mice during decitabine treatment.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 12 2022
23 12 2022
Historique:
received:
14
06
2022
accepted:
20
12
2022
entrez:
23
12
2022
pubmed:
24
12
2022
medline:
28
12
2022
Statut:
epublish
Résumé
Treatment of myelodysplastic syndromes includes the administration of the hypomethylating agent decitabine. An early platelet response in decitabine-treated myelodysplastic syndrome patients is a predictor of overall survival. The effect of decitabine on megakaryocytes and the bone marrow, however, is understudied. We show that an early platelet increment was not detectable in healthy mice during decitabine treatment. Analyses of bone marrow sections revealed vessels with dilated lumina, decreased cellularity, but increased number of red blood cells and the presence of (pro)platelet-like particles. Taken together, decitabine treatment of healthy mice does not induce an early platelet increment, but affects the bone marrow.
Identifiants
pubmed: 36564544
doi: 10.1038/s41598-022-26821-8
pii: 10.1038/s41598-022-26821-8
pmc: PMC9789030
doi:
Substances chimiques
Decitabine
776B62CQ27
Azacitidine
M801H13NRU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22266Informations de copyright
© 2022. The Author(s).
Références
Arch Histol Cytol. 2003 May;66(2):123-43
pubmed: 12846553
Blood Rev. 2013 Sep;27(5):243-59
pubmed: 23954262
Expert Rev Hematol. 2013 Oct;6(5):611-24
pubmed: 24094045
Thromb Haemost. 2011 Aug;106(2):337-43
pubmed: 21713321
Epigenetics. 2006 Jan-Mar;1(1):7-13
pubmed: 17998812
Nat Rev Cancer. 2012 Dec;12(12):849-59
pubmed: 23175121
Int J Cancer. 2008 Jul 1;123(1):8-13
pubmed: 18425818
Oncol Lett. 2016 Apr;11(4):2347-2352
pubmed: 27073478
Br J Haematol. 2020 Jun;189(5):e194-e197
pubmed: 32207144
Oncotarget. 2015 Jun 30;6(18):16653-62
pubmed: 25938546
J Clin Oncol. 2011 May 20;29(15):1987-96
pubmed: 21483003
Br J Haematol. 2011 Dec;155(5):599-606
pubmed: 21981697
N Engl J Med. 2020 Oct 1;383(14):1358-1374
pubmed: 32997910
Thromb Haemost. 2015 May;113(5):1021-34
pubmed: 25566808
Br J Haematol. 2014 Oct;167(1):62-8
pubmed: 24995683